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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(1): 3-10


Influence of enalapril on endotheliun-dependent contractile reactionsand oxygen cost of work of smoothmuscles at experimental diabetesmellitus

O.D. Prysyazhna, A.V. Kotsyuruba,M.N. Tkachenko, V.V. Sagach.

    О.О. Bogomolets Institute of PhysiologyNational Academy of Sciences of Ukraine, KyivA.V. Palladin Institute of Biochemistry National Academy of Sciences of Ukraine, Kyiv


Abstract

The influence of angiotensin-converting enzyme on endotheliun-dependent contractile vascular reactions was investigated on the rat model of streptozotocin-induced diabetes mellitus. It is shown, that the long-term administration of enalapril results in partial restoration of disturbed at diabetes mellitus reactions and also to reduction of oxygen cost of smooth muscles and myocar- dial work. Thus, after 28-day’s of oral adminis- tration of this drug the restoration of endotheliun- dependent dilatation of aorta and coronary ves- sels, increase of stretch-induced contractile responses of vascular smooth muscles, reduction of stiffness of isolated portal vein strips are ob- served. Possible mechanisms of such changes are following: increase of nitric oxide synthesis (at the expense of constitutive NOS activity ) and reduction of oxidative stress, to what the decrease of diene conjugates contents in tissues of animals with diabetes mellitus after long introduction of enalapril testifies.

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