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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(1): 3-10

Influence of enalapril on endotheliun-dependent contractile reactionsand oxygen cost of work of smoothmuscles at experimental diabetesmellitus

O.D. Prysyazhna, A.V. Kotsyuruba,M.N. Tkachenko, V.V. Sagach.

    О.О. Bogomolets Institute of PhysiologyNational Academy of Sciences of Ukraine, KyivA.V. Palladin Institute of Biochemistry National Academy of Sciences of Ukraine, Kyiv



Abstract

The influence of angiotensin-converting enzyme on endotheliun-dependent contractile vascular reactions was investigated on the rat model of streptozotocin-induced diabetes mellitus. It is shown, that the long-term administration of enalapril results in partial restoration of disturbed at diabetes mellitus reactions and also to reduction of oxygen cost of smooth muscles and myocar- dial work. Thus, after 28-day’s of oral adminis- tration of this drug the restoration of endotheliun- dependent dilatation of aorta and coronary ves- sels, increase of stretch-induced contractile responses of vascular smooth muscles, reduction of stiffness of isolated portal vein strips are ob- served. Possible mechanisms of such changes are following: increase of nitric oxide synthesis (at the expense of constitutive NOS activity ) and reduction of oxidative stress, to what the decrease of diene conjugates contents in tissues of animals with diabetes mellitus after long introduction of enalapril testifies.

Full text: (PDF, in Ukrainian)

References

  1. Березовский В.А. Напряжение кислорода в тканяхживотных и человека. – К.: Наук. думка, 1975. – 277 с.
  2. Браунвальд Е., Росс Дж., Зонненблик Е.Х. Механизмысокращения сердца в норме и при недостаточности.– М.: Медицина, 1974. – 176 с.
  3. Гаврилов В.Б., Гаврилова А.Р., Хмара Н.Ф. Изме-рение диеновых конъюгатов в плазме крови по УФ-поглощению гептановых и изопропанольныхэкстрактов // Лаб. дело. – 1988. – № 2. – С. 60–64.
  4. Коваленко Е.А., Березовский В.А., Эпштейн И.М.Полярографическое определение кислорода ворганизме. – М.: Медицина, 1975. – 230 с.
  5. Присяжна О.Д., Коцюруба А.В., Ткаченко М.М.,Сагач В.Ф. Механізми зміни скорочувальних реакційта ефективності використання кисню гладенькимим’язами ворітної вени за умов експериментальногоцукрового діабету // Фізіол. журн. – 2006. – 52,№ 1. – С. 8–16.
  6. Сагач В.Ф., Присяжна О.Д., Ткаченко М.М.,Коцюруба А.В. Вплив L-аргініну на функціональнуактивність ендотелію за умов експериментальногоцукрового діабету // Там само. – 2005. – 51, № 2. –С. 3–7.
  7. Сагач В.Ф., Ткаченко М.М., Присяжна О.Д. та ін.Зміни вазодилататорних реакцій судинних гладенькихм’язів та системи оксиду азоту за умов експери-ментального цукрового діабету // Там само. – 2003. –49, № 4. – С. 24–32.
  8. Хаютин В.М., Рогоза А.И. Регуляция кровеносных со-судов, порождаемая приложенными к ним меха-ническими силами. – В кн.: Руководство по физио-логии. Физиология кровообращения. Регуляциякровообращения. – Л. : Наука, 1986. – С. 37–66.
  9. 9. Хаютин В.М., Рогоза А.Н. Методы исследованиякровообращения / Под. ред. Б.И. Ткаченко. – Л.:Наука, 1976. – 275 с.
  10. 10. Arnal J.F., Yamin J., Dockery S., Harrison D.G.Regulation of endothelial nitric oxide synthase mRNA,protein, and activity during cell growth // Amer. J.Physiol. – 1994. – 267, № 5, Pt 1. – P. C1381–C1388.
  11. Bonnefont-Rousselot D., Bastard J.P., Jaudon M.C.,Delattre J. Consequences of the diabetic status on theoxidant/antioxidant balance // Diabetes Metab. – 2000. –26, № 3. – P. 163–176.
  12. Brown B.P., Heistad D.D. Capacitance of the rabbitportal vein and inferior vena cava // J. Physiol.(London). – 1986. – 381, № 1. – P. 417–425.
  13. Chin S.Y., Pandey K.N., Shi S.J. et al. Increased activi-ty and expression of Ca2+-dependent NOS in renalcortex of ANG II-infused hypertensive rats // Amer. J.Physiol. – 1999. – 277, № 5, Pt 2. – P. F797–F804.
  14. Da Ros R., Assaloni R., Ceriello A. Antioxidant therapyin diabetic complications: what is new? // Curr. Vasc.Pharmacol. – 2004. – 2, № 4. – P. 335–341.
  15. Desco M.C., Asensi M., Marquez R. et al. Xanthineoxidase is involved in free radical production in type 1diabetes: protection by allopurinol // Diabetes. – 2002. –51, № 4. – P. 1118–1124.
  16. Giacchetti G., Sechi L.A., Rilli S., Carey R.M. Therenin-angiotensin-aldosterone system, glucose metabo-lism and diabetes // Trends Endocrinоl. and Metab. –2005. – 16, № 3. – P. 120–126.
  17. Giugliano D., Ceriello A., Paolisso G. Oxidative stressand diabetic vascular complications // Diabetes Care. –1996. – 19, № 3. – P. 257–267.
  18. Johansson B., Mellander S. Static and dynamiccomponents in the vascular myogenic response to pas-sive changes in length as revealed by electrical andmechanical recordings from the rat portal vein //Circulat. Res. – 1975. – 36, № 1. – P. 76–83.
  19. 19. Kirpichnikov D., Sowers J.R. Diabetes mellitus anddiabetes-associated vascular disease // Trends Endo-crinol. and Metab. – 2001. – 12, № 5. – P. 225–230.
  20. 20. Kojda G., Harrison D.G. Interactions between NO andreactive oxygen species: pathophysiological importancein atherosclerosis, hypertension, diabetes and heart fail-ure // Cardiovasc. Res. – 1999. – 43, № 3. – P. 562–571.
  21. Lefroy D.C., Crake T., Uren N.G. et al. Effect of inhi-bition of nitric oxide synthesis on epicardial coronaryartery caliber and coronary blood flow in humans //Circulation. – 1993. – 88, № 1. – P. 43–54.
  22. Neely J.R., Liebermeister H., Battersby E.J., MorganH.E. Effect of pressure development on oxygen con-sumption by isolated rat heart // Amer. J. Physiol. –1967. – 212, № 4. – P. 804–814.
  23. Pieper G.M., Mei D.A., Langenstroer P., O’RourkeS.T. Bioassay of endothelium-derived relaxing factorin diabetic rat aorta // Ibid. – 1992. – 263, № 3. –P. H676–H680.
  24. Salter M., Knowles R.G., Moncada S. Widespread tissuedistribution, species distribution and changes in activityof Ca2+-dependent and Ca2+-independent nitric oxidesynthases // FEBS Lett. – 1991. – 291, № 1. – P. 145–149.
  25. Tesfamariam B., Cohen R.A. Free radicals mediate endot-helial cell dysfunction caused by elevated glucose // Amer.J. Physiol. – 1992. – 263, № 2, Pt2. – P. H321–326.
  26. Toop M.J., Dallinger K.J., Jennings P.E., Barnett A.H.Angiotensin-converting enzyme (ACE): relationshipto insulin-dependent diabetes and microangiopathy //Diabetic Med. – 1986. – 3, № 5. – P. 455–457.
  27. Vanhoutte P.M. Endothelium–dependent contractionsin arteries and veins // Blood Vessels. – 1987. – 24,№ 3. – P. 141–144.
  28. Vodovotz Y., Kwon N.S., Pospischil M. et al. Inactiva-tion of nitric oxide synthase after prolonged incuba-tion of mouse macrophages with IFN-gamma and bac-terial lipopolysaccharide // J. Immunol. – 1994. – 152,№ 8. – P. 4110–4118.
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