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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(5): 21-27

Neuroprotective effect of quercetin under experimental brain ischemia

T.M.Kovalenko, I.O.Osadchenko, O.M.Tsupikov, T.A.Pivneva, A.S.Shalamai, O.O.Moibenko,G.G.Skibo

    O.O. Bogomoletz Institute of Physiology National Academyof Sciences of Ukraine, Kyiv



The neuroprotective action by water-soluble form of querce- tin was examined in gerbils after transient forebrain ischemia. The animals were exposed to 7 min of bilateral common carotid artery occlusion. Hippocampal CA1 area was examined 7 days after ischemia-reperfusion. The average density of CA1 pyra- midal neurons and GFAP-positive glial cells were counted in sham operated group, in ischemiс group and in the groups treated with water-soluble form of quercetin. It was shown that quercetin revealed protective effect by decreasing of de- layed neuronal death and reducing reactive astrogliosis after ischemia-reperfusion.

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