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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(5): 21-27


Neuroprotective effect of quercetin under experimental brain ischemia

T.M.Kovalenko, I.O.Osadchenko, O.M.Tsupikov, T.A.Pivneva, A.S.Shalamai, O.O.Moibenko,G.G.Skibo

    O.O. Bogomoletz Institute of Physiology National Academyof Sciences of Ukraine, Kyiv


Abstract

The neuroprotective action by water-soluble form of querce- tin was examined in gerbils after transient forebrain ischemia. The animals were exposed to 7 min of bilateral common carotid artery occlusion. Hippocampal CA1 area was examined 7 days after ischemia-reperfusion. The average density of CA1 pyra- midal neurons and GFAP-positive glial cells were counted in sham operated group, in ischemiс group and in the groups treated with water-soluble form of quercetin. It was shown that quercetin revealed protective effect by decreasing of de- layed neuronal death and reducing reactive astrogliosis after ischemia-reperfusion.

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