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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(5): 6-11


Role of mitochondria in reglulation of endothelialhyperpolarization to acetylcholine

A.І. Bondarenko, V.F. Sagach

    О.О.Bogomoletz Institute of Physiology National Academy ofSciences of Ukraine, Kyiv


Abstract

We investigated the regulation of sustained endothelial hyper- polarization to acetylcholine in the rat aortic endothelial cells by mitochondria. Protonofore CCCP and rotenone, an elec- tron transport chain complex I inhibitor, agents that cause mitochondria depolarization, inhibited the sustained hyper- polarization of endothelial cells. This effect was unlikely to be mediated by the free radicals since hydrogen peroxide was shown to hyperpolarize endothelial cells. It is concluded that mitochondrial Ca2+ uptake is essential in prolongation of en- dothelial hyperpolarization to acetylcholine.

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