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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(4): 40-46


Influence of carbahol and atropine on the motor cortex neurons in cat duringoperant reflex

E.A. Schyglo

    O.O. Bogomoletz Institute of Physiology National Academyof Sciences of Ukraine, Kyiv


Abstract

Effects of carbachol and atropine on the caused and back- ground impulse neurons activity during operant reflex were studied on twenty motor cortex neurons. Motor cortex neurons in dependence of changes impulse neurons activity after carbachol administration have been divided into two groups; the first group includes neurons with a long influence on im- pulse activity and the second – with short. Carbachol applied by ionophoresis to motor cortex promoted authentic increase of background impulse activity and duration of the caused reaction in both groups. Abministration of atropine, an an- tagonist of m-cholinergic receptors significantly reduced pa- rameters of background impulse activity and duration of the caused reaction. It was suggested that acetylcholine released by terminals of the cholinergic fibers in natural conditions takes part in maintenance of motor cortex neuron background activity and provides sufficient intensity of the motor commands generated by these cells; the given effects mediated by m-cholinergic receptors

References

  1. Батуев А.С. Функции двигательного анализатора. – М.: Изд-во Ленинград. ун-та, 1970. – 224 с.
  2. Чернышев Б.В., Майоров В.И., Москвитин А.А. Облегчение и угнетение под влиянием йонофоре- тической аппликации ацетилхолина разных компо- нентов реакций нейронов двигательной коры при выполнении условного рефлекса постановки лапы на опору // Журн. высш. нерв. деятельности. – 1998. – 48, №1. – С. 99–112.
  3. Acquas E., Wilson C., Fibiger H.C. Condotioned and un- conditioned stimuli increase frontal cortical and hippoc- ampal acetylcholine release: effects of novelty, habitua- tion, and fear // J. Neurosci. – 1996. – 16, № 9. – P. 3089–3096.
  4. Kievet J., Kuypers H.G. J. Basal forebrain and hypo- thalamic connections to the frontal cortex and parietal cortex in the Rhesus monkey // Science. – 1975. – 187, № 4177. – P. 660–662.
  5. Lamour Y., Dutar P., Jobert A., Dykes R.W. An iono- phoretic study of single somatosensory neurons in ratgranular cortex serving the limbs: a laminar analysis of glutamate and acetylcholine effects on receptive-field properties // J. Neurophysiol. – 1988. – 60. – P. 725–750.
  6. Markram H., Segal M. Tne inositol 1,4,5-triphosphate pathway mediates cholinergic potentiation of rat hippocampal neuronal responses to NMDA // J. Physiol. – 1992. – 447. – P. 513–533.
  7. Mesulam M.M., Van Hoesen G.W. Acetylcholinest- erase-rich projections from the basal forebrain of the Rhesus monkey to neocortex // Brain Res. – 1976. – 109, № 1. – P. 152–157.
  8. Metherate R., Tremblay N., Dykes R.W. Transient and prolonged effects of acetylcholine on responsiveness of cat somatosensory cortical neurons // J. Neuro- physiol. – 1988. – 59, №4. – P. 1253–1276.
  9. 9. Reiner P.B., Semba K., Fibiger H.C., McGeer E. G. Physiological evidence of cortically projecting basal forebrain neurons in the anaesthetized rat // Neuro- science. – 1987. – 20, № 2. – P. 629–636.
  10. 10. Rose S.P.R., Gibbs M.E., Hambley J. Transient in- crease in forebrain muscarinic avoidance learning in the young chick // Ibid. – 1980. – 5, №1. – P. 169–178.
  11. Sarter M., Bruno J.P. Trans-synaptic stimulation of cortical acetylcholine and enhancement of attention function: a rational approach, for the development of cognition enhancers // Behav. Brain Res. – 1997. – 83, № 1–2. – P. 7–14.
  12. Swartz B.E., Woody C.D. Correlated effects of acetyl- choline and cyclic guanosine monophosphate on membrane properties of mammalian neocortical neurons // J. Neurobiol. – 1979. – 10. – P. 465–488.
  13. Wenk H., Bigl V., Mayer U. Cholinergic projections from magnocellular nuclei of the basal forebrain to cortical areas in rats // Brain Res. Rev. – 1980. – 2, № 9. – P. 295–316.
  14. Woody C.D., Swartz B.E., Gruen E. Effects of acetylcho- line and cyclic GMP on input resistance of cortical neurons in awake cats // Ibid. – 1978. – 158. – P. 373–395.
  15. Woody C. Gruen E. Responses of morphologically iden- tified cortical neurons to intracellularly injected cyclic AMP // Exp. Neurol. – 1986. – 91. – P. 596–612.

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