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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(4): 33-39


Antioxidantsmodification of ionizing irradiation and additional stress effects upon rats higher nervousactivity

E.V. Tukalenko, V.V. Varetsky, A.G. Rakochi, I.R. Dmitrieva, M.JU. Makarchuk

    Scientific Center for Radiation Medicine of Academy ofMedical Sciences of Ukraine;Kyiv National Shevchenko University, Kyiv, Ukraine


Abstract

The aim of this study was to investigate the oxidative effect of the low-level radiation upon the higher nervous activity. Be- havioral (shuttle-box) and statistical methods were used. The effect of the ionizing radiation (0,05 Gy) upon the indices of rats behavioral reaction as well as ability of some antioxidants (alpha-tocopherol, ascorbic acid, beta-carotene) used sepa- rately and in complex to diminish exposure effects on the indices studied have been investigated Beta-carotene demon- strated the largest protective effect alone and as a component in complex compound. Alpha-tocopherol used in animal exposured to the dose of 0,05 Gy, could case decline of the rats behavior reactions indices; this suggest that use of antioxidant therapy demands certain cautiousness. The results obtained suggest dominant role of the oxidant stress during ionizing radiation at least in dose of 0,05 Gy.

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