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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(4): 19-23


Influence of citostatic iphosphomid on the function of thewhite rat kidneys

A.I. Gozhenko, M.V. Trusova

    O.O. Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv



Abstract

Influence of the single injection of iphosphomid on kidney function during 24 hours after injection under functional load- ing (water and saline) was investigated. It was established that the single injection of iphosphomid to white rats led to changes of renal function manifested by decrease of creatinine clearence as well as tubular transport. It was shown that saline loading resulted in weakening of renal functional reserve accompanied by significant proteinuria, glucoseuria and disturbances of os- moregulation.

References

  1. Берхин Е.Б., Иванов Ю.И. Методы эксперимен- тального исследования почек и водно-солевого обмена. – Барнаул.: Алтай. кн. изд-во, 1972. – 199 с.
  2. Возіанов О.Ф., Гоженко А.І., Федорук О.С. Гостра ниркова недостатність. – Одеса: Одес. мед. ун-т, 2003. – 375 с.
  3. Гоженко А.И. Энергетическое обеспечение основных почечных функций и процессов в норме и при повреждении почек: Автореф. дис. … д-ра мед. наук. – Черновцы,1987. – 36 с.
  4. Гоженко А.І., Роговий Ю.Є., Федорук О.С. та ін. „Приховане” ушкодження проксимального відділу нефрону // Одес. мед. журн. – 2001. – №5. – С.16 – 19.
  5. Гоженко А.І. Роль оксиду азоту в молекулярно- клітинних механізмах функції нирок // Укр. біохім. журн. – 2002. – 74, № 4а. – С. 96.
  6. Кучер А.Г., Каюков И.Г., Есаян А.М., Ермаков Ю.А. Влияние количества и качества белка в рационе на деятельность почек//Нефрология. – 2004. – 8, №2. – С.14–34.
  7. Михеева А.И., Богодарова И.А. К методике определения общего белка в моче на ФЭК-Н-56 // Лаб. дело. – 1969. – №7. – С.441–442.
  8. Пахмурный Б.А. О механизме действия сердечных гликозидов на функцию почек и водно-солевой обмен: Автореф. дис. … д-ра мед. наук. – Новоси- бирск,1969. – 39 с.
  9. 9. Boddy A.V., English M., Pearson A.D. et al. Ifosfamide nephrotoxicity: limited influence of metabolism and mode of administration during repeated therapy in paediatrics//Eur. J. Cancer. – 1996. – 32A, №7. – P.1179–1184.
  10. 10. Earle K. A., Mehrotra S., Dalton R. N. et al. Defective nitric oxide production and functional renal reserve in patients with type 2 diabetes who have microalbuminuria of african and asian compared with white Origin //J. Amer. Soc. Nephrol. – 2001. – №12. – P.2125–2130.
  11. Foxall P.J., Lenz E.M., Lindon J.C. et al. Nuclear mag- netic resonance and high-performance liquid chromato- graphy-nuclear magnetic resonance studies on the toxi- city and metabolism of ifosfamide // Ther. Drug. Monit. – 1996. – 18, №4. – P.498–505.
  12. Roels H.A., Hoet P., Lison D. Usefulness of biomarkers of exposure to inorganic mercury, lead, or cadmium in controlling occupational and environmen- tal risks of nephrotoxicity // Ren. Fail. – 1999. – 21, №3–4. – P.251–262.
  13. Rossi R., Godde A., Kleinebrand A. et al. Concentrating capacity in ifosfamide-induced severe renal dysfunc- tion // Ibid. – 1995. – 17, №5. – P.551–557.
  14. Stuben J., Port R., Bertram B. et al. Pharmacokinetics and whole-body distribution of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard and its effects on the incorporation of [methyl – 3H]-thymidine in various tissues of the rat // Cancer Chemother. Pharmacol. – 1996. – 38, №4. – P.355–365.
  15. Van Vleet T.R., Schnellmann R.G. Toxic nephropathy: environmental chemicals // Semin. Nephrol. – 2003. – 23, №5. – P.500–508.
  16. Wainer I.W., Ducharme J., Granvil C.P. The N- dechloroethylation of ifosfamide: using stereochemis- try to obtain an accurate picture of a clinically relevant metabolic pathway // Cancer Chemother. Pharmacol. – 1996. – 37, №4. – P.332–336.

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