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Influence of citostatic iphosphomid on the function of thewhite rat kidneys
A.I. Gozhenko, M.V. Trusova
O.O. Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv
Abstract
Influence of the single injection of iphosphomid on kidney
function during 24 hours after injection under functional load-
ing (water and saline) was investigated. It was established that
the single injection of iphosphomid to white rats led to changes
of renal function manifested by decrease of creatinine clearence
as well as tubular transport. It was shown that saline loading
resulted in weakening of renal functional reserve accompanied
by significant proteinuria, glucoseuria and disturbances of os-
moregulation.
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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