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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(4): 19-23


Influence of citostatic iphosphomid on the function of thewhite rat kidneys

A.I. Gozhenko, M.V. Trusova

    O.O. Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv


Abstract

Influence of the single injection of iphosphomid on kidney function during 24 hours after injection under functional load- ing (water and saline) was investigated. It was established that the single injection of iphosphomid to white rats led to changes of renal function manifested by decrease of creatinine clearence as well as tubular transport. It was shown that saline loading resulted in weakening of renal functional reserve accompanied by significant proteinuria, glucoseuria and disturbances of os- moregulation.

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