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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(4): 13-18


Inhibitors of mitochondrial permeabilitytransition pore take part in prevention of apoptosis of dopaminergic neurons in themesencephalon in rat

S.A. Talanov, V.F. Sagach, N.N. Oleshko, V.A. Maisky

    O.O. Bogomoletz Institute of Physiology National Academyof Sciences of Ukraine, Kyiv


Abstract

In the study the role of apoptosis in development of dopam- inergic neuronal cell death within substantia nigra (parts compacta) and ventral tegmental area induced by 6-OHDA was investigated. It was found that intermittent hypoxia and the water-soluble vitamine E (Trolox) and melatonin, as anti- oxidants and inhibitors of mitochondrial permeability transi- tion pore protect dopaminergic cells from cytotoxic effect of 6-OHDA. It is supposed that mitochondrial permeability tran- sition pore plays an important role in apoptosis of neurons in the brain.

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