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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(4): 9-12


Non-hydrolysable diadenosine polyphosphate analoguemodulates signal transduction in hippocampal slices

Sergei Melnik, Michael Wright, Julian A. Tanner, Vera Tsintsadze, Timur Tsintsadze, AndrewD. Miller and Natalia Lozovaya

    Odessa State Medical University, Ministry of Health ofUkraine


Abstract

The modulatory effect of endogenous diadenosine polyphos- phates on synaptic transmission in the rat hippocampal slices has been re-examined with a non-hydrolysable Ap4A analogue diadenosine-5',5'»-P1,P4-[?,?-methylene]tetraphosphate (AppCH2ppA). We have shown that AppCH2ppA at low micromolar concentrations induce inhibition of orthodromically evoked population spikes, without affecting of excitatory postsynaptic currents and antidromic spikes recorded in the CA1 zone of hippocampus. Such a spatially selective neuronal inhibition may influence dendritic electrogenesis in pyramidal neurons and consequently mediate control of neuronal net- work activity in hippocampus.

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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.