|
|
|
|
Development of visceral pain under influence of the nociceptive stimule and geneticfactors
B. S. Sushko
O.O.Bogomoletz Institute of Physiology National Academy ofSciences of Ukraine, Kyiv
![](/images/cite.png)
Abstract
The experimental research of painful behavioural
reaction on nociceptive visceral stimulus with
outinbred white and of the C57BL/6J and CBA/
CaLac genetic strains of mice was carried out. In-
fluence of intraperitoneal administration of the dif-
ferent volumes and concentration of acetic acid so-
lution on visceral painful behavioural reaction at
these animals was shown. It was found that CBA/
CaLac had a higher intensity of visceral painful
behavioural reaction (on 32 %), than C57BL/6J
strain. Comparison of intensity of behavioural
reactions to a somatic pain in these animals (the
formalin test) has shown that at CBA/CaLac this
intensity was lower by 48.5 % than in C57BL/6J strain. Such
distinctions in the character of behavioural reactions on so-
matic and visceral pain may be caused by features of the func-
tional organization of the brain central structures participating
in the formation of visceral and somatic reflexes at these two
genetic strains.
References
- Аршавский И. А. Физиологические механизмы и закономерности индивидуального развития. – М.: Наука, 1982. – 268 с.
- Бландова З. К., Душкин В. А., Малашенко А. М. и др. Линии лабораторных животных для медико-биологи- ческих исследований. – М.: Наука, 1983. – 192 с.
- Коплик Е. В. Метод определения критерия устойчи- вости крыс к эмоциональному стрессу // Вестн. новых мед. технологий. – 2002. – 9, № 1. – С. 16–18.
- Кодряшова Н. Н., Сытников А. П. Effect of emotionality, exploratory activity and pain sensitiv- ity on manifestation of agonistic behavior in the mouse // Журн. высш. нерв. деятельности им. И.П. Павлова. –1986. – 36, № 4. – С. 686–691.
- Лиманский Ю. П. Рефлексы ствола головного мозга. – К.: Наук. думка, 1987. – 240 с.
- Сушко Б. С., Будак А. В. Особливості больової реакції та чутливості тварин різних генетичних груп // Фізіол. журн. – 2004. – 50, № 2. – С. 75–79.
- Черниговский В. В. Интероцепция. – Л.: Наука, 1985. – 413 с.
- Юматов Е. А., Мещеряков О. Л. Прогнозирование устойчивости к эмоциональному стрессу на основе индивидуального тестирования поведения // Журн. высш. нерв. деятельности им. И.П. Павлова. – 1990. –40, № 3. – С. 575.
- 9. Avgustinovich D. F., Lipina T. V., Kudriavtseva N. N. Response of the serotoninergic brain system to social stress of various duration in male mice C57BL/6J and CBA/Lac // Ross. Fiziol. Zh. Im. I. M. Sechenova. –2001. – 87, № 4. – P. 532–542.
- 10. Belzung C., El Hage W., Moindrot N., Griebel G. Be- havioral and neurochemical changes following preda- tory stress in mice // Neuropharmacology. – 2001. – 41, № 3. – P. 400–408.
- Daughters R. S., Rivard, R., Simone D. A., Reichert J. A. Peripheral and preemptive opioid antinociception in a mouse visceral pain model // Pain. – 2001. – 89, № 2–3. – P. 221–227.
- Ferraro T.N., Golden G.T., Smith G.G. et al. Mouse strain variation in maximal electroshock seizure thresh- old // Brain Res. – 2002. – 936, № 1–2. – P. 82–86.
- Garcia-Nicas E., Cervero F., Martinez-Caro L., Laird J. M. A new model of visceral pain and referred hype- ralgesia in the mouse // Pain. – 2001. – 92, № 3. – P. 335–342.
- Gebhart G. F., Joshi S. K. Visceral pain // Current review of pain. – 2000. – 4, №6. – P. 499–506.
- Kawashima N., Fugate J., Kusnecov A. Immunologicalchallenge modulates brain orphanin FQ/nociceptin and nociceptive behavior // Brain. Res. – 2002. – 949, № 1–2. – P.71.
- Ladabaum U., Owyang C. Pathobiology of visceral pain: molecular mechanisms and therapeutic implications V. Central nervous system processing of somatic and vis- ceral sensory signals // Amer. J. Physiol. – gastrointest. and liver Physiol. – 2000. – 279, № 1. – С. 1–6.
- Laird J. M., Olivar T., Roza C. et al. Deficits in vis- ceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene // Neuroscience. – 2000. – 98, № 2. – P. 345–352.
- Mogil J.S., Lichtensteiger C.A., Wilson S.G. The ef- fect of genotype on sensitivity to inflammatory nociception: characterization of resistant (A/J) and sensitive (C57BL/6J) inbred mouse strains // Pain. –2000. – 84, № 1. – P. 111–112.
- 19. Raffa R.B., Mathiasen J.R., Kimball E.S., Vaught J.L. The combined immunological and antinociceptive de- fects of beige-J mice: the possible existence of a “mu- repressin” // Life Sci. – 1993. – 52, № 1. – P.1–8.
- 20. Wilson S. G., Chesler E. J., Hain H. et al. Identifica- tion of quantitative trait loci for chemical/inflammatory nociception in mice // Pain. – 2002. – 96, № 3. –P. 385–391
|
|
|
|
|
|
|