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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(3): 78-83


Development of visceral pain under influence of the nociceptive stimule and geneticfactors

B. S. Sushko

    O.O.Bogomoletz Institute of Physiology National Academy ofSciences of Ukraine, Kyiv


Abstract

The experimental research of painful behavioural reaction on nociceptive visceral stimulus with outinbred white and of the C57BL/6J and CBA/ CaLac genetic strains of mice was carried out. In- fluence of intraperitoneal administration of the dif- ferent volumes and concentration of acetic acid so- lution on visceral painful behavioural reaction at these animals was shown. It was found that CBA/ CaLac had a higher intensity of visceral painful behavioural reaction (on 32 %), than C57BL/6J strain. Comparison of intensity of behavioural reactions to a somatic pain in these animals (the formalin test) has shown that at CBA/CaLac this intensity was lower by 48.5 % than in C57BL/6J strain. Such distinctions in the character of behavioural reactions on so- matic and visceral pain may be caused by features of the func- tional organization of the brain central structures participating in the formation of visceral and somatic reflexes at these two genetic strains.

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