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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(3): 3-14


Melatonin recoversischemic tolerance and decreases the sensitivity of mitochondrial permeability transition poreopening in old rat heart

V.F. Sagach, O.V. Rudyk, G.L. Vavilova, A.V. Kotsiuruba, Ju.P. Tkachenko

    O. O. Bogomolets Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv;O. V. Palladin Institute of Biochemistry, National Academy ofSciences of Ukraine, Kyiv


Abstract

The effect of the hormone of pineal gland melatonin on the ischemic tolerance and the sensitivity of mitochondrial perme- ability transition pore opening in old rat heart were studied. It has been shown in the Langendorf’s isolated rat heart that heart contractile functional changes under ischemia and reperfusion were more pronounced in old (24-27 months) rat hearts in comparison with the adult (5-6 months) animals. A two-week’s in vivo course of intraperitoneal injection of mela- tonin (1,5 mg/kg weight) to old rats contributed to the rehabili- tation of the functional changes of isolated heart after ischemia during reperfusion and decreased the sensitivity of mitochon- drial permeability transition pore opening to Са2+ and phenilarsinoxide in comparison with old animals which did not received melatonin. It was accompanied by the significant decreasing in mRNA bax expression in old rat heart, lessening in content of the superoxide radicals and dien conjugates and twice increasing in the activity of constitutive NO–synthase in heart mitochondria of old rat after a course of melatonin injection. The protective feffect of melatonin on the mito- chondrial permeability transition pore opening could be used for correction of the cardiac dysfunction with aging.

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