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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(1): 82-88

Alteredability to learn in posterity of rats with iodine defficiency

T.G. Tsintsadze, G.O. Gabrichidze, N.I. Lazrishvili, D.S. Metreveli, N.P. Mitagvariya

    Tbilisi State Medical University, Tbilisi, Georgia



Abstract

Experimental data demonstrate that hypothyroidism could result in depressive behavior and subsequently thyroid hormones could act as antidepressants. Postnatal changes in learning ability, memory and emotional status in posterity of rats, which have experienced different level of iodine defi- ciency before conception and during all gestation period were investigated in this study. Results obtained suggest that sud- den iodine deprivation before and during gestation led to a significant neurological defect, which was represented by loss of ability to learn, one of the most important functions of brain in newborn and by evidence of depression. Iodine sup- ply to the diet of female rats eliminates these effects completely

Full text: (PDF, in Ukrainian)

References

  1. Митагвария Н.П. Устойчивость циркуляторного обеспечения функций головного мозга. –Тбилиси:Мецниереба, 1983.
  2. Buresh.J., Bureshova O., Huston J. Techniques and Basic Experiments for the Study of Brain and Behav- ior.– Amsterdam, New York, Oxford: Elsevier Scien-tific Company, 1976.
  3. Calvo R.M., Obregom M.J., Ruiz de Ona C. et al. Com- genital HY pothyroidism as studied in rats. Crucial roleof maternal thyroxine but not of 3,5,3'-triiodthyronine inthe protection of the fetal // J. Clin Invest.– 1990. – 86. –P. 889–899.
  4. Guadan-Ferraz A., Escamez M.J., Raussell J. Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of speciffic primary sensory systerms //Neurosci.– 1999. – 19. – P. 3430–3439.
  5. Hetzel B.S. Iodine Deficiency Disorders and their Eradication // Lancet.– 1983. – 2. – P. 1126–1129.
  6. Illig R., Largo R.H., Qin Q. et al. Mental development in congenital hypothyroidism after neonatal screen-ing//Areh. Dis. Child. – 1987. – 62. – P. 1050–1055.
  7. Martinez-Galan J.R., Pedraza P., Santacana M. Early effect of lodine deficiency on radial glial cells of the hippocampus of the rat fetuset// J. Clin Invest. – 1997. –99. – P. 2701–2709.
  8. Morreale de Escobar G., Obregom M.J., Escobar del Rey F. Is Neuropsychological. Development related to maternal hypothyroidism or to maternal hypothy-xinemia? // J. Clin. Endocrinol. and Metabol.– 2000. –85, № 11. – P. 3975–3987.
  9. 9. Morreale de Escobar G., Obregom M.J., Escobar del Rey F. Role of thyroid hormone during early brain develop-ment // Europ.J. Endocrinol. – 2004. – 151. – P. 25–37.
  10. 10. Redei E.E., Solberg L.C., Kluezynski J.M., Pare W.P. Paradoxical hormonal and behavioral responses to hy- pothyroid and hyperthyroid states in the Wistar-Kyoto rat // Neuropsychopharmacology. – 2001. – 24,№6. – P. 632–639.
  11. Ruiz de Ona C., Obregom M.J., Escobar del Rey F., Morreale de Escobar G. Development changes in rat brain 5'-deiodinase and thyroid hormones during the fetal pe-riod: the effect of fetal hypothyroidism and maternal thy-roid hormones // Pediatr. Res. – 1988. – 24. – P. 588–594.
  12. Xue-Yi C., Xin-Min J., Zhi-Jong D. et al. Timing of vulnerability of the brain to iodine deficiency in en-demic cretinism // N. Engl. J. Med. – 1994. –331. –P. 1739–1744.
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