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Alteredability to learn in posterity of rats with iodine defficiency
T.G. Tsintsadze, G.O. Gabrichidze, N.I. Lazrishvili, D.S. Metreveli, N.P. Mitagvariya
Tbilisi State Medical University, Tbilisi, Georgia
Abstract
Experimental data demonstrate that hypothyroidism could
result in depressive behavior and subsequently thyroid
hormones could act as antidepressants. Postnatal changes in
learning ability, memory and emotional status in posterity of
rats, which have experienced different level of iodine defi-
ciency before conception and during all gestation period were
investigated in this study. Results obtained suggest that sud-
den iodine deprivation before and during gestation led to a
significant neurological defect, which was represented by loss
of ability to learn, one of the most important functions of
brain in newborn and by evidence of depression. Iodine sup-
ply to the diet of female rats eliminates these effects completely
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