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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(6): 37-39

Effectiveness of intravenousimmunoglobulin treatment in ratswith experimental allergicencephalomyelitis

M.I. Lysiany, V.O. Melnik, L.M. Belska.

    O.О. Bogomoletz National Medical University, Kyiv;A.P. Romodanov Institute of Neurosurgery AMS of Ukraine,Kyiv



Abstract

The aim of our study was to investigate effectiveness of intra- venous immunoglobulin treatment at experimental allergic encephalomyelitis (EAE). EAE was induced by the adminis- tration of adult rat spinal cord homogenates with Freund’s adjuvant. All rats were divided into three groups: the first group received intraperitoneal injections of human intrave- nous immunoglobulin in dose 0,5 g/kg from 12th to 16th day after induction of EAE; the second group received intraperito- neal injections of rat intravenous immunoglobulin in dose 0,5 g/kg from 12th to 15th day after induction of EAE; and the third group was a control group. We observed more rapid and full recovery from EAE in rats treated with intravenous immunoglobulin.

Full text: (PDF, in Ukrainian)

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