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Effects of bradykinin and capsaicininjections into feline m. gastrocne-mius-soleus on stretch-evokedpostsynaptic responsein homosynaptic motoneurones
L.A. Bugaychenko, A.I. Pilyavskii, A.I. Kostyukov.
O.O.Bogomoletz Institute of Physiology, NAS of Ukraine,Kyiv
Abstract
Responses of gastrocnemius-soleus motoneurones to stretches
of the homonymous muscles were recorded intracellularly in
63ISSN 0201-8489
the decerebrated cats during intramuscular injections (IMI) of
bradykinin or capsaicin into the muscles. Effects of IMI on
EPSPs and spikes evoked by stretches of the G-S muscles
were studied in 6 motoneurones. Stretch-evoked EPSPs and
firing were predominantly suppressed after IMIs, with the
exception of slight increase of EPSPs up to 150 s after brady-
kinin injection, followed by theirs distinct decrease. The sup-
pression of spike activity was followed by restoration within
500–800 s after bradykinin injection. Stretch-evoked EPSPs
and firing were depressed after capsaicin injection; control
level of motoneurones activity was seemed to be unrecoverable
for quite a long time. No background IPSPs were observed
after algesic injections and presynaptic inhibition was
considered as plausible reason for the observed suppression
of motoneurones activity.
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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