Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(5): 79-84

Serum creatine kinase levels and thenumber of sarcolemmal dystrophindisruptions in human skeletal musclefibers under conditionsof supportlessness

N.M. Gasnikova, A.A. Markin, I.B. Kozlovskaya,I.M. Larina, B.S. Shenkman.

    RF SRC – Institute of Biomedical Problems of RussianAcademy of Sciences, Moscow, Russia



Abstract

9 male volunteers took part in the experiment. They were divided in two groups. 5 volunteers (control group) have been in “dry” immersion for 7 days. 4 volunteers (stimulated group) in addition to “dry” immersion were treated with artificial support stimulation. We investigated the number of muscle fibers with the disruptions of sarcolemmal dystrophin and serum creatine kinase levels. 7-day “dry” immersion did not change the mean number of muscle fibers with dystrophin disruptions, it led to significant decrease of serum creatine kinase levels and did not influence on the sensitivity of sarco- lemma to injury. Artificial support stimulation did not influ- ence on these parameters.

Full text: (PDF, in Ukrainian)

References

  1. Blake D.J., Weir А., Newey S.E., Davies K.E. Func-tion and Genetics of Dystrophin and Dystrofin-Related Proteins in Muscle // Phisiol Rev. – 2002. –82. – P. 291–329.
  2. Chockalingam P.S., Cholera R., Oak S.A. et al.Dystrophin-glycoprotein complex and Ras and RhoGTPasse signaling are altered in muscle atrophy // Amer.J. Physiol. Cell. Physiol. – 2002. – 283. – C500–C511.
  3. Chopard A., Leclerc L., Muller J. et al. Effect of a 14-day spaceflight on dystrophin associated proteinscomplex in rat soleus muscle // J. Grav. Physiol. –1998. – 5(1). – P. 67–68.
  4. Chopard A., Pons F., Marini J. Cytoskeletal proteincontents before and after hindlimb suspension in a fastand slow rat skeletal muscle // Amer. J. Physiol. – 2001.– 280. – R323–R330.
  5. Clarke M.S., Bamman M.M., Feeback D.I. Bed restdecreases mechanically induced myofiber wounding andconsequent wound-mediated FGF release // J. Appl.Physiol. – 1998. –85(2). – P. 593–600.
  6. Dworzak A.E., Secnik P., Parrak V. et al. Changes inmuscular proteins during simulated microgravity // J.Neurol. Sci. – 1993. – 119(1). –P. 119–20.
  7. Kozlovskaya I., Dmitrieva I., Grigorieva L. et al. Gravi-tational mechanisms in the motor system. Studies inreal and simulated weightlessness. – In: Stance andMotion. – New York, 1987. – P. 37–48.
  8. Lovering R.M., De Deyne P.G. Contractile function,sarcolemma integriti, and the loss of dystrophin afterskeletal muscle eccentric contraction-induced injury //Amer. J. Physiol. Cell. Physiol. – 2004. – 286. – С230-С238.
  9. 9. Markin A., Strogonova L., Balashov O. et al. The dy-namics of blood biochemical parameters in cosmonautsduring long-term space flights // Acta Astronautica. –1998. –42. – P. 247–253.
  10. 10. Rezvani M., Ornatsky O.I. Connor M.K. et al.Dystrophin, vinculin, and aciculin in skeletal musclesubject to chronic use and disuse // Med. Sci. SportsExerc. – 1996. – 28. – P. 79–84.
  11. Shenkman B.S., Goncharova S.A., Stroganova L.B. etal. Muscle derived serum enzyme accumulation after+gz acceleration test in rhesus monkeys exposed to bedrest // J. Grav. Physiol. – 2000. – 7(2). – P. 101–102.
  12. Totsuka Manabu, Shigeyuki Nakaji, Suzuki et al. Breakpoint of serum creatine kinase release after enduranceexercise // J. Appl. Physiol. – 2002. – 93. – P. 1280–1286.
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.