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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(5): 65-70


Experimental photodynamic therapyof tumors with 5-ala

N.F. Gamaleia, V.V. Kutsenok, O.B.Gorobets,M.O. Lozinsky, A.N. Borisevich, V.V.Holin.

    R.E.Kavetsky Institute for Experimental Pathology, Oncologyand Radiobiology, NAS of Ukraine; Institute of OrganicChemistry, NAS of Ukraine; “Photonics plus”, Ukraine


Abstract

The photodynamic therapy (PDT) of Lewis carcinoma in с57Вl/6 mice and sarcoma 180 in random bred mice was carried out with 5-aminolaevulinic acid (ALA) used as a photosensi- tizer. It has been shown that ALA-PDT effectively inhibited the growth of Lewis carcinoma and sarcoma 180, decreased the frequency of metastatic spreading and the number of me- tastases to lung in mice with Lewis carcinoma. It is concluded that PDT with ALA is a potentially perspective method of tumor treatment.

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