Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(5): 31-36


The heme oxygenase induction in ratheart and vessels and the peroxidativeresistence of rat erythrocytes underhemolytic anemia development

P. A. Kaliman, O.V. Pavichenko.

    Харків. нац. ун-т ім. В.Н.Каразіна М-ва освіти танауки України


Abstract

The hemolytic anemia development caused by phenylhydra- zine injection (7 mg/100 g b.w.) was shown to be caused by the decreasing of both catalase activity and glutathione content in erythrocytes, and by the increasing of spontaneouse hemolysis level of these cells in blood stream. The increasing of heme oxygenase activity and TBA-active products in rat heart and vessels were revealed 24 hrs after phenylhydrazine injection. Possible mechanisms of heme oxygenase-1 induction under hypoxia as response to the hemolytic anemia development and it’s role in defense of the cells from damage are discussed.

References

  1. Гублер Е.В., Генкин А.А. Применение непарамет-рических критериев статистики в медико-биологическихисследованиях. – Л.: Медицина, 1973. – 144 с.
  2. Дубинина Е.Е., Ефимова Л.Ф., Софронова Л.Н.,Геронимус А.Л. Сравнительный анализ активностисупероксиддисмутазы и каталазы эритроцитов и цельнойкрови у новорожденных детей при хронической гипоксии// Лаб. дело. – 1989. – №9. – С. 16–19.
  3. Каліман П.А., Стрельченко Е.В., Бараннік Т.В. таін. Метаболізм гему та гемопротеїнів і деякіпоказники антиоксидантної системи в еритроцитах ітканинах щурів при фенілгідразиновій анемії //Фізіол. журн. – 2003. – 49, №2. – С. 66–72.
  4. Макаренко Е.В. // Лаб. дело. – 1998. – 11. – С. 48–50.
  5. Путилина Ф.Е. Определение содержания восстанов-ленного глутатиона в тканях. – В кн.: Методыбиохимических исследований / Под ред. ПрохоровойМ.И. –1982. –С. 183–185.
  6. Саркисов Д.С., Ремезов П.И. Воспроизведениеболезней человека в эксперименте. – М.: Моск.правда, 1960. – 780 с.
  7. Физиология человека : Пер. с англ. под руковод-ством Р. Шмидта и Г. Тевса. – М.: Мир, 1996. – 323 с.
  8. Applegate L.A., Luscher P., Tyrrel R.M. Induction ofheme oxygenase a general response to oxidative stressin cultured mammalian cells // Canc.Res. – 1991. – 51(3). –Р. 974–978.
  9. 9. Balla J., Nath K.A., Balla G. et al. Endothelial cellheme oxygenase and ferritin induction in rat lung byhemoglobin in vivo // Amer. J. Physiol. Lung Cell Mol.Physiol. – 1995. – 268. – Р. 321–327.
  10. 10. Bottomley R. H. Metabolic adaptation in rat hepato-mas // Cancer Res. – 1963. – 23, №3. – Р. 400–409.
  11. Carraway M.S., Yhio A.J., Carter J.D. Expression ofheme oxygenase-1 in the lung chronic hypoxia // Amer.J. Physiol. Lung. Cell. Mol. Physiol. – 2000. – 278(1). –Р. 806–812.
  12. Ciccoli L., Signorini C., Alessandrini C. Iron release,lipid peroxidation and morphological alterations oferythrocytes exposed to acrolein and phenylhydrazine// Exp.Mol.Pathol. – 1994. – Р. 108–118.
  13. Deindl E., Kolar F., Neubauer E. et al. Effect of inter-mittent high altitude hypoxia on gene expression in ratheart and lung // Physiol.Res. – 2003. – 52(2). –Р. 147–157.
  14. Grabellus F., Schmid C., Levkau B. Reduction of hy-poxia-inducible heme oxygenase-1 in the myocardiumafter left ventricular mechanical support // J. Pathol. –2002. – 197(2). – Р. 230–237.
  15. Jager F.C. Determination of vitamin E requirement inrats by means of spontaneous haemolysis in vitro //Nutr. Dieta. – 1968, №10. – С. 215–223.П. А. Каліман, О. В. Павиченко
  16. 63ISSN 0201-8489 Фізіол. журн., 2005, Т. 51, № 5
  17. Lee P.J., Jiang B.H., Chin B.Y. et al. Hypoxia-induc-ible factor-1 mediares transcriptional activation of theheme oxygenase-1 gene in response to hypoxia // J.Biol. Chem. – 1997. – 272(9). – Р. 5375–5381.
  18. Lu R., Peng J., Xiao L. et al. Heme oxygenase-1 path-way is involved in delayed protection induced by heatstress against cardiac ischemia-reperfusion injury //Int.J.Cardiol. – 2002. – 82(2). – Р. 133–140.
  19. Maines M.D. The heme oxygenase system: a regulatorof second messenger gases. – Annu. Rev. Pharmacol.and Toxicol. – 1997. – 37. – Р. 517–554.
  20. 19. Maines MD, Kappas A. Prematurelly evoked synthesisand induction of d-aminolevulenat synthetase neonatal.Evidence for metal ion repression of enzime formation //J. Biol. Chem. – 1978. –253. – Р. 2312–2336.
  21. 20. Mayer M. Association of serum bilirubin concentrationwith risk of coronary artery disease // Clin. Chem. –2000. – 46. – Р. 1723–1727.
  22. Miller G.L. Protein determination for large numbers ofsamples // Anal. Chem. – 1959. – 31(5). – Р. 964.
  23. Morita T., Perrella MA, Lee ME, Kourenbanas S.Smooth muscle cell-derived carbon monoxide is regulatorof vascular cGMP // Proc.Natl.Acad.Sci.USA. – 1995. –92. – Р. 1475–1479.
  24. Morse D., Choi A.M.K. Heme Oxygenase-1. Theemerging molecule has arrived // Amer. J. Respir. Cell.Mol. Biol. – 2002. – 27(1). – Р. 8–16.
  25. Nakayama М., Takahashi K., Kitamuro T. et al.Repression of heme oxygenase-1 by hypoxia in vascu-lar endothelial cells // Biochem. and Biophys. Res.Commun. – 2000. – 271(3). – Р. 665–671.
  26. Ndisang J.F., Zhao W., Wang R. Selective regulation onblood pressure by heme oxygenase-1 in hypertension // Hypertension. – 2002. – 40(3). – Р. 315–321.
  27. Ohara A. N-phenylprotoporphyrin IX formation inthe hemoglobin-phenylhydrazine reaction // J. Biol.Chem. – 1981. – 257(11). – Р. 6231–6242.
  28. Ortiz de Montellano, Kerr D.E. Inactivation of catalaseby phenylhydrazine. Formation of a stable eryl-ironheme complex // J. Biol. Chem. – 1983. – 258(17). –P. 558–10563.
  29. Otterbein L.E., Choi A.M. Heme oxygenase: colors ofdefense against cellular stress // Amer. J. Physiol. Lung.Cell. Mol. Physiol. – 2000. – 279(6). – Р. 029–1037.
  30. 29. Paul K.G., Theorel H., Akeson A. The molar light ab-sorption of pyridine ferroprotoporphyrin (Pyridinehaemochromogen) // Acta Chem. Scand. – 1953. – 7(9). –Р. 1284–1287.
  31. 30. Yachie A., Niida Y., Wada T. et al. Oxidative stressenhanced endothelial cell injury in human heme oxyge-nase-1 deficiency // J. Clin. Invest. – 1999. – 103(1). –Р. 129–135.
  32. Yan S.F., Ogawa S., Stern D.M., Pinsky D.J. Hypoxia-induced modulation of endothelial cell properties:regulation of barrier function and expression ofinterleukin-6 // Kidney Int. – 1997. – 51. – Р. 419–425.
  33. Zhang F, Kaide I.J., Yang L. et al. Carbon MonoxideModulates the Pulmonary Vascular Response to AcuteHypoxia: Relation to Endothelin // Amer. J. Physiol.Heart. Circ. Physiol. – 2003. – р. 3.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.