Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(4): 36-44

Evoked potentials of the somaticcortex (fields 4, 6), thalamus (vl, vpl)and emg reactions of the cat shoulder muscles elicited by elbowjoint extension in norm and afterinjection of toxin mptp

G. V. Dovgalets.

    O.O. Bogomoletz Institute of Physiology, National Academyof Science of Ukraine, Kyiv



Abstract

EMG activity from the elbow joint muscles and evoked po- tentials (ep) from the somatic cortex (fields 4, 6) and thalamic nuclei (vl, vpl) elicited by passive extension were recorded in the unanesthetized cats before and after MPTP injection (to- tal dose 10 mg/kg). It was shown, that after MPTP injection changes of the EMG response in cats are similar to that ob- served in parkinsonian patients. The increase of amplitude and duration of the stretch-related m2-3 –components of EMG, as well as excitation increase in thalamus and cortex was shown after MPTP. Perturbation of an external extensor loading ap- plied to the forearm with different fixed force moments elic- ited m. biceps brachii EMG reactions which amplitude in norm correlated with a muscle stretch size. The MPTP injection influenced this dependence. Contrary to EMG responses n26- 60 amplitude of the thalamic and cortical EP did not depend on the level of muscle stretch neither in norm nor after MPTP injection. Hence it supposed that an afferent excitation, which was responsible for this EP, did not take part in a generation of the m2-components of the stretch reflex. Late (n100) component’s amplitude of the thalamic nuclei EP depended on the muscle stretch level. After MPTP injection this relation disappeared just as in the EMG responses. Since m2 components aroused in the spinal cord motor neurons earlier than n100 components in thalamus it is supposed that excita- tion of shoulder muscle receptors and spinal neurons, which provided with origin of m2 components consisting of EMG responses, were responsible for generation of the EP late components of thalamic nuclei VL and VPL.

Full text: (PDF, in Ukrainian)

References

  1. Атаджанов М. А. Паркинсонизм и 1-метил-4-фенил-1,2,3,6-тетрагидропиридин // Журн. невропатологиии психиатрии. – 1991. – 91, №4. – С. 117–121.
  2. Довгалец Г. В., Тальнов А. Н. Вызванные потен-циалы соматической коры и ЭМГ-реакции мышцплеча ненаркотизированной кошки, возникающие вответ на пассивное разгибание локтевого сустава //Нейрофизиология. – 2004. – 36, № 3. – 230–241.
  3. Зеленская В.С.,Волошин М.Я.,Охрименко Л.В.Изменения активности нейронов вентролате-рального ядра таламуса и двигательных компонентовинструментальной реакции у кошек после систем-ного введения N-метил-4-фенил-1,2,3,6-тетра-гидропиридина (МФТП) // Там же. – 1990. – 22,№3. – С.291–300.
  4. Сторожук В.М. Функциональная организациянейронов соматической коры. – К.: Наук. думка,1974. – С. 17–23.
  5. Albin R.L., Young A.B., Penny J.B. The functionalanatomyof basal ganglia disorders // TINS. – 1989. –12, №10. – P.366-375.
  6. Aminoff M.J., Siedenberg R., Goodin D.S. Changes offorearm EMG and cerebral evoked potentials follow-ing sudden muscle stretch during isometric contrac-tions in patients with Parkinson’s disease // Brain Res.– 1997. – 757, №2. – P. 254–259.
  7. Berardelli A., Sabra A.F., Hallett M. Physiologicalmechanisms of rigidity in Parkinson’s disease // J. Neurol.Neurosurg. Psychiatry. – 1983. – 46, №1. – P. 45–53.
  8. Burke D., Hagbarth K. E., Wallin B. G. Reflex mecha-nisms in Parkinsonian rigidity // Scand. J. Rehab. Med. –1977. – 9. – P. 15–23.
  9. 9. Chez С., Shinoda Y. Spinal mechanisms of the func-tional stretch reflex // Exp. Brain Res. – 1978. – 32,№ 1. – P. 55–68.
  10. 10. Doudet D.J., Gross C., Arluison M., Bioulac B. Modi-fications of precentral cortex discharge and EMG ac-tivity in monkeys with MPTP-induced lesions of DAnigral neurons // Ibid. – 1990. – 80, № 1. – P. 177–188.
  11. Goldberg J.A., Boraud T., Maraton S.et al. Enhancedsynchrony among primary motor cortex neurons in the1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine pri-mate model of Parkinson’s disease // J. Neurosci. –2002. – 22, № 11. – P. 4639–4653.
  12. Hummelsheim H., Wiesendanger M., Bianchetti M. Thesupplementary motor area modulates perturbation-evoked discharges of neurons in the precentral motorcortex // Neurosci. Let. –1986. – 67. – P. 119–122.
  13. Landgren S., Olsson K.A. Low Threshold afferent pro-jections from the oral cavity and the face to the cere-bral cortex of the cat // Exp. Brain Res. – 1980. – 39,№2. – P.133–147.
  14. Lee R. G. Pathophysiology of rigidity and akinesia inParkinson’s disease // Eur. Neurol. – 1989. – 29. – P. 13–18.
  15. Lee R. G., Tatton W. G. Motor responses to suddenlimb displacements in primates with specific CNS le-sions and in human patients with motor system disor-ders // Can. J. Neurol. Sci. –1975. – 2, №3. – P. 285–293.
  16. Lorenc-Koci E., Wolfarth S., Ossowska K. Haloperi-dol-increased muscle tone in rats as a model of parkin-sonian rigidity // Exp. Brain Res. – 1996. – 109, № 2. –P. 268–276.
  17. Marsden C. D., Rothwell J. C., Day B. L. Long-latencyautomatic responses to muscle stretch in man: originand function. – In: Motor Control Mechanisms inHealth and Disease. – New York, Raven Press, 1983. –P. 509–539.
  18. Roland P.E., Zilles K. Functions and structures of themotor cortices in humans // Curr. Opin. in Neurobiol. –1996. – 6. – P. 773–781.
  19. 19. Rothwell J. C., Obeso J. A., Traub M. M., Marsden C.D. The behaviour of the long-latency stretch reflex inpatients with Parkinson’s disease // J. Neurol., Neuro-surg and Psych. – 1983. – 46. – P. 35–44.
  20. 20. Scholz E., Diener H. C., Noth J. et al. Medium andlong-latency EMG responses in leg muscles: Parkin-son’s disease // Ibid. – 1987. – 50. – P. 66–70.
  21. Seiss E., Praamstra P., Hesse C. W., Rickards H. Prop-rioceptive sensory function in Parkinson’s disease anddisease: evidence from proprioception-related EEG potential // Exp. Brain Res. – 2003. – 148,№ 3. – P. 308–319.
  22. Suarez F.R. Topographischer Hirnatlas der Katze. –Darmstadt: Herausgegeben von E. Merck, 1961.
  23. Voloshin M.Ya., Lukhanina E.P., Kolomietz B.P. etal. Electrophysiological investigation of thalamicneuronal mechanisms of motor disorders in parkin-sonism: an influence of D2ergic transmission block-ade on excitation and inhibition of relay neurons inmotor thalamic nuclei of cat // Neurosci. – 1994. – 62,№3. – P. 771–781.
  24. Voloshin M.Ya., Zelenskaya V.S., Lukhanina E.P. et al.Influence of N-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine-induced injury of dopaminergic nigrostriatalsystem on movement components of the instrumentalreflex and motor thalamic neurons’ reactions in the cat// Ibid. – 1991. – 45, № 2. – P.291–305.
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.