The influence of non-selective alpha-adrenergic receptors antagonistnicergoline on the motor thalamicneuronal activity
O.P. Lukhanina, N.A. Pilkevich.
O.O. Bogomoletz Institute of Physiology, National Academyof Science of Ukraine, Kyiv
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Abstract
In experiments on rats microionophoretic administration of
nicergoline mainly showed the dual effect on the background
activity of the ventrolateral thalamic nucleus (VL) neurons
and their reactions evoked by the superior cerebellum pe-
duncle stimulation: inhibitory under weak (2-10 nA) and exci-
tatory under stronger (20-40 nA) currents. Microionophoresis
(25 nA) of nicergoline led to decrease of the postexcitatory
inhibitory processes during paired stimulation of the cerebel-
lum fibers. Paired-pulse ratio (number of spikes in the short-
latency neuronal responses elicited by the second pulse /
number of spikes by the first pulse) increased, which support
a presynaptic mode of drug action. Hence excitatory effect of
nicergoline may be related to the blockade of the presynaptic
alpha2-receptors, while inhibitory effect by the blockade of
the postsynaptic alpha1-receptors. Present data reveal the
essential participation of the alpha-adrenoreceptor system in
the modulation of background and evoked neuronal activity of
the motor thalamus. The possible role of noradrenergic dener-
vation in the development of movement disorders accompa-
nying Parkinson’s disease is discussed.
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