Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(4): 29-35


The influence of non-selective alpha-adrenergic receptors antagonistnicergoline on the motor thalamicneuronal activity

O.P. Lukhanina, N.A. Pilkevich.

    O.O. Bogomoletz Institute of Physiology, National Academyof Science of Ukraine, Kyiv


Abstract

In experiments on rats microionophoretic administration of nicergoline mainly showed the dual effect on the background activity of the ventrolateral thalamic nucleus (VL) neurons and their reactions evoked by the superior cerebellum pe- duncle stimulation: inhibitory under weak (2-10 nA) and exci- tatory under stronger (20-40 nA) currents. Microionophoresis (25 nA) of nicergoline led to decrease of the postexcitatory inhibitory processes during paired stimulation of the cerebel- lum fibers. Paired-pulse ratio (number of spikes in the short- latency neuronal responses elicited by the second pulse / number of spikes by the first pulse) increased, which support a presynaptic mode of drug action. Hence excitatory effect of nicergoline may be related to the blockade of the presynaptic alpha2-receptors, while inhibitory effect by the blockade of the postsynaptic alpha1-receptors. Present data reveal the essential participation of the alpha-adrenoreceptor system in the modulation of background and evoked neuronal activity of the motor thalamus. The possible role of noradrenergic dener- vation in the development of movement disorders accompa- nying Parkinson’s disease is discussed.

References

  1. Карасевич Н.В., Луханина Е.П., Гаркавенко В.В. идр. Влияние альфа-адреноблокатора (сермион) наэффективность комплексной патогенетическойтерапии больных болезнью Паркинсона // Укр.вісн. психоневрології. - 2001. - 9, вип.4 (29). -C. 92–97.
  2. Babiuch M. Comparison of the effect of vincamineand nicergoline in the treatment of ischemic stroke //Neurol. Neurochir. Pol. - 1999. - 33, № 2. -P. 503–505.
  3. Bartlett E.L., Smith P.H. Effects of paired-pulse andrepetitive stimulation on neurons in the rat medial gen-culate body // Neuroscience. - 2002. - 113, № 4. -P. 957-974.
  4. Carpenter M.B. Connectivity patterns of thalamicnuclei implicated in dyskinesia // Stereotact. Funct.Neurosurg. - 1989. - 52, № 2/4. - P. 79–119.
  5. Devilbiss D.M., Waterhouse B.D.. Norepinephrinetwo distinct profiles of action on sensorycortical neuron responses to excitatory synaptic stimuli// Synapse. - 2000. - 37, № 4, - P. 273–282.
  6. Dugast C., Cespuglio R., Suaud-Chagny M.F. In vivomonitoring of evoked noradrenaline release in the ratanteroventral thalamic nucleus by continuous ampero-metry // J. Neurochem. - 2002. - 82, № 3. - P. 529–537.
  7. Eccles J.C., Katz B., Kuffler S.W. Nature of the “endplate potential” in curarized muscle // J. Neurophysiol. -1941. - 4. - P. 362–387.
  8. Fioravanti M., Flicker L. Efficacy of nicergoline indementia and other age associated forms of cognitiveimpairment // Cochrane Database Syst. Rev. - 2001. -4. - CD003159.
  9. 9. Gaspar P., Duyckaerts C., Alvarez C. et al. Alterationsof dopaminergic and noradrenergic innervations inmotor cortex in Parkinson’s disease // Ann. Neurol. -1991. - 30, № 3 - P. 365–374.
  10. 10. Hornykiewicz O., Pifl C. The validity of the MPTPprimate model for the neurochemical pathology of id-iopathic Parkinson’s disease. - In: NoradrenergicMechanisms in Parkinson’s Disease. - Madras : CRCрress, 1994. - P. 11–23.
  11. Jones E.G. The Thalamus. - New York : Plenum рress,1985. - 935 p.
  12. Kombian S.B., Ananthalakshmi K.V., Parvathy S.S.,Matowe W.C. Substance P depresses excitatory syn-aptic transmission in the nucleus accumbens throughdopaminergic and purinergic mechanisms // J. Neuro-physiol. - 2003. - 89, № 2. - P. 728–737.
  13. Lehmenkuhler C., Walden J., Speckmann E.J. Decreaseof N-methyl-D-aspartate responses by noradrenalinein the rat motorcortex in vivo // Neurosci. Let. - 1991. -121, № 1–2. - P. 5–8.
  14. Levenes C., Daniel H., Soubrie P., Crepel F. Cannabinoidsdecrease excitatory synaptic transmission and impairlong-term depression in rat cerebellar Purkinje cells // J.Physiol. - 1998. - 510, part 3. - P. 867–879.
  15. Lukhanina E.P., Pilkevich N.A. Roles of alpha-adrenoreceptors in cerebello-cortical transmission inthe rat // Нейрофизиология /Neurophysiology. - 2002. -34, № 2/3. - P. 188–191.
  16. Lukhanina E.P., Kolomiets B.P., Pilkevich N.A. Effectof stimulation of beta-adrenergic receptors on neuronalactivity in primary motor cortex of the rat // Neurosci.Let. - 2003. - 340, № 2. - P. 99–102.
  17. Marie R.M., Barre L., Rioux P. et al. PET imaging ofneocortical monoaminergic terminals in Parkinson’sdisease // J. Neural. Transm. - Parkinson’s Disease andDementia. - 1995. - 9, № 1. - P. 55–71.
  18. Neher E. Vesicle pools and Ca2+ microdomains: newtools for understanding their roles in neurotransmitterrelease // Neuron. - 1998. - 20, № 3. - P. 389–399.
  19. 19. Oke A.F., Carver L.A., Gouvion C.M., Adams R.N.Three-dimensional mapping of norepinephrine and se-rotonin in human thalamus // Brain Res. - 1997. - 763,№ 1. - P. 69–78.
  20. 20. Parisi V., Colacino G., Milazzo G. et al. Effects ofnicergoline on the retinal and cortical electrophysiologi-cal responses in glaucoma patients: a preliminary openstudy // Pharmacol. Res. - 1999. - 40, № 3. - P. 249–255.
  21. Paxinos G., Watson C. The Rat Brain in StereotaxicCoordinates. - New York : Academic Press, 1997. - Fig.52.
  22. Pifl C., Schingnitz G., Hornykiewicz O. Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on theregional distribution of brain monoamines in the rhesusmonkey // Neuroscience. - 1991. - 44, № 3. - P. 591–605.
  23. Pilkowska E., Jakubowska T., Witkowska K.,Kulczycki J. Nicergoline in the treatment of patientsafter a mild ischemic stroke // Neurol. Neurochir. Pol. -2002. - 36, № 6. - P. 1075–1085.
  24. Rivner M., Sutin J. Locus coeruleus modulation of the mo-tor thalamus: inhibition in nuclei ventralis lateralis and ven-tralis anterior // Exp. Neurol. - 1981. - 73, № 3 - P. 651–673.
  25. Rouiller E.M., Liang F., Babalian A. et al. Cerebello-thalamocortical and pallidothalamocortical projectionsto the primary and supplementary motor cortical areas:a multiple tracing study in macaque monkeys // J.Comp. Neurol. - 1994. - 345, № 2. - P. 185–213.
  26. Saletu B., Paulus E., Linzmayer L. et al. Nicergoline insenile dementia of Alzheimer type and multi-infarctdementia: a double-blind, placebo-controlled, clinicaland EEG/ERP mapping study // Psychopharmacology(Berl.). - 1995. - 117, № 4. - P. 385–395.
  27. Shen K.-Z., Johnson S.W. Presynaptic GABA-B andadenosine A1 receptors regulate synaptic transmissionto rat substantia nigra reticulata neurones // J. Physiol. -1997. - 505, part 1. - P. 153–163.
  28. Shinoda Y., Futami T., Kakei S. Input-outputorganization of the ventrolateral nucleus of the thala-mus // Stereotact. Funct. Neurosurg. - 1993. - 60, № 1–3. - P. 17–31.
  29. 29. Zhang C., Guo Y.Q., Qiao J.T., Dafny N. Locuscoeruleus modulates thalamic nociceptive responsesvia adrenoceptors // Brain Res. - 1998 - 784, № 1–2. -P. 116–122

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.