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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(4): 13-19


The role of nitric oxidein the development of humoralimmune response in mice

I.M.Alexeyeva, T.M.Bryzgina,L.I.Alexyuk, T.V.Martynova, V.S.Sukhina.

    O.O. Bogomoletz Institute of Physiology, National Academyof Science of Ukraine, Kyiv


Abstract

The immune response in CBA mice was evoked by injection of sheep erythrocytes. The number of antibody-producing cells in the spleen, as well as nitric oxide production, oxygen- dependent metabolism and 5“-nucleotidase activity of perito- neal macrophages and lymphocytes were studied on days 1-5- 14 after immunization. It was shown that during the inductive phase of the immune response (day 1), the peritoneal cells increased nitric oxide production, while later their functional activity increased and NO level became normal. The use of NO-synthase inhibitors (non-selective L-NNA and iNOS in- hibitors SMT and dexamethasone) increased the immune response and decreased the macrophage functional activity. The use of NO-donator SNP resulted in reverse effect: de- crease of the immune response and stimulation of peritoneal cells functional activity. The data obtained indicate that nitric oxide participates in the immune response regulation, in par- ticular, through the suppressive effect of macrophages.

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