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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(3): 88-91


The comparative study of the newfluorine-containing guanidine-derivate compounds and pinacidil’sinfluence on the contractile func-tion of a urinary bladder in vitro

I. Limarenko

    Institute of Pharmacology and Toxi


Abstract

The effects of the new fluorine-containing guanidine-derivate compounds on bladder contractile function were examined on isolated bladder strips in vitro. Female rats (250-350 g) were used. The bladder was removed and placed in the room temperature PSS of the following composition (mM): NaCl (118.4), KCl (4.7), CaCl2 (2.5), MgSO4 (1.2), KH2PO4(1.2), NaHCO3 (24.9), and D-glucose (11.1) gassed with O2-CO2, 95%-5%. The base of the bladder was then cut into strips 4-to 5-mm wide and 10-mm long. Then strips were pretensioned (0.25-0.5 g) and after 30min of equilibration were contracted with an additional 60mM KCl and again were allowed to equilibrate. Compounds were administered directly into the tissue bath. All compounds produced a concentration- dependent relaxation of isolated rat bladder strips.

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