Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(3): 78-82


The peculiarities of operated nerveregeneration under subcompensatedarterial ishemia and venoushypertension in experiment

О.O.Goncharuk, V.I Tsimbaljuk, Kostinskij G.B.

    A. Romodanov Institute of Neurosurgery, Academy ofMedical Sciences of Ukraine, Kyiv


Abstract

The submitted work is devoted to a problem of influence of the regional hemodynamic disturbances on nerve regeneration following its full anatomic breakdown and neuroraphy. In a chronic experiment on 30 white rats, an arterial ischemia was reproduced by ligation of the main femoral arteries: common and deep femoral (12 animals), while venous hypertension was reproduced by ligation of the main veins: common, deep femoral and big hypodermic veins (12 animals). In the second stage of the operation a sciatic nerve of the same limb was dissected and its pieces were connected by perineural seam. In the control group 6 animals were subjected to the operation with the subsequent imposition of the perineural seam on the sciatic nerve. In 7, 14, 30, 60, 90 days after operation the tissue block from a zone of neural anastomosis was deleted. Proximal and distal stumps of the operated nerve, reclaiming neuroma and hematomicrocirculating channels of the nerve were investigated by perfusion, histologic and electron- microscopic methods. It is established that the regional is- chemia caused by trauma of the main arteries of the limb re- sulted in inhibition of regenerative processes in the operated nerve, and restoration of arterial blood circulation is essential for stimulation of these processes. Regional venous hypertension is not the critical factor for regeneration of a peripheral nerve after its anatomic breakdown and microsurgical neuroraphy.

References

  1. Березовская Т.А., Евлоев С.И., Щербак Н.П.Нейрососудистые расстройства в условиях експери-ментальной ишемии нервних стволов. – В кн.:Заболевание ПНС. – Новосибирск, 1985. – С. 48–52.
  2. Берснев В.П., Яковенко И.В., Семенютин В.Б, КокинГ.С. Хирургическое лечение поврежденных нервовс учетом их кровотока и данных интраоперационнойдиагностики // Метод. рекомендации. – Л., 1991. – 12 с.
  3. Крупаткин А.Н. Клиническая нейроангиофизио-логия конечностей. – М.: Науч. мир, 2003. – 328 с.
  4. Левицкий В.А., Юрах Е.М. Микроциркуляторноерусло периферических нервов и его потенциальныерезервы. – В кн.: Научно-технический прогресс, охранаокружающей среды, фундаментальные проблемымедицины и биологии / Полтава, 1988. – С. 204–205.
  5. Родионов И.М., Тарасова О.С., Кошелев В.Б. Адап-тация резистивных сосудов к уровню трансму-рального давления// Рос. физиол. журн. им. И.М.Сеченова. – 2001. – 87, № 11. – С.1477–1487.
  6. Флебология / Под ред. В.С. Савельева. – М.:Медицина, 2001. – 66 с.
  7. Чайковский Ю.Б. Микрореваскуляризация седалищ-ного нерва в условиях его де- и регенерации:Автореф. дис. … канд.мед.наук. – К., 1977. – 20 с.
  8. Sunderland S. Nerves and nerve injuries / 2nd ed. –Edinburgh: Churchill Livingstone, 1978. – 839 p.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.