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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(2): 96-103

Transformation of electrical activityin the myelinated nerve fibres ofamphibia by 4-aminopyridine

I.V. Kuznetzova, D.A. Evstigneev, N.V. Gluhova




Abstract

Using the extracellular recording we studied the effect of 4- aminopyridine (4-AP), a potassium channel blocker on the electrical activity of the myelinated nerve fibres of amphibia Rana ridibunda Pallas. Two main types of the reaction on 4- AP were established: extension of the action potential and multi-spike response. In some cases the nerve fibres with multi-spike response generated spontaneous activity without stimulation in the form of bursts of action potentials. During repetitive stimulation 4-AP decreased after-depolarization (at the beginning of the stimulation), the posttetanic after-depo- larization and the development of posttetanic after-hyperpolar- ization. Using the paired stimulation it was established that the spike and after-depolarization of the second action potential depended on the size of after-depolarization after the first action potential. The effects of 4-AP were strongly time-dependent.

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