The effect of l-arginine on thefunctional activity of endotheliumunder experimental diabetes mellitus
V.F. Sagach, O.D. Prysyazhna,M.N. Tkachenko, A.V.Kotsuruba
O.O. Bogomolets Institute of Physiology National Academyof Sciences of Ukraine, KyivA.V. Palladin Institute of Biochemistry National Academy ofSciences of Ukraine, Kyiv
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Abstract
The experimental data about the shift of L-arginine metabo-
lism in the direction of activization of non-oxidizing (arginase)
way under experimental diabetes mellitus are presented. This
shift was proved by an increase of the ratio of arginase and
NO-synthase activity and an increase of the ratio of their
metabolites. The decrease of the free L-arginin contents in
tissues of animals with experimental diabetes mellitus is shown.
The long infusion of L-arginine results in the restoration of the
endothelial function, however cessation of infusion results in a
gradual reduction of this effect.
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