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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(1): 88-94

Gastric secretion and mucosal bloodflow during simultaneous inhibitionof m1-cholinergic receptors andl-са[sup]2+[/sup]-channels in anaesthetized rats

A. Sklyarov Y. Mandryk

    Lviv National Medical University named after DanyloGalytsky



Abstract

The gastric secretion and gastric mucosal blood flow (GMBF) under simultaneous action of M1-cholinergic antagonist gastrocepine (3 mg/kg i.v.) and L-Са2+-channels blocker verapamile (1.25 mg/kg i.v.) were investigated in urethane- anaesthetized rats. The stomach was perfused with saline, and GMBF was measured by using hydrogen gas clearance tech- nique. The acid production under combined action of both blockers was lower by 57.3 % and 18.6 %, than in case of separate action of gastrocepine and verapamile accordingly. Pepsin concentration decreased by 32 %, which did not differ from verapamile action alone. The above changes of gastric secretion was accompanied by significant decrease of GMBF. Inhibition of M1-cholinergic receptors by gastrocepine did not show their key role in basal gastric secretion in rats, but they exacerbate L-Са2+-channels blocker action. We conclude, that enhance of acid output inhibition is related to the simulta- neous depression of nervous impulses in ganglionic neurons and acethylcholine release from parasympathetic postgangli- onic neurons. Synchronous block of M1-cholinergic receptors and L-Са2+-channels of smooth muscles stomach vessels resulted in reducing of gastric mucosal blood flow.

Full text: (PDF, in Ukrainian)

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