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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2000; 46(4): 101-117


Endothelial Factorsin the Regulation of the Na+, K+-Atpase Activity

Vavilova G. L., Akopova O. V., Sagach V. F

    A. A. Bogomoletz Institute of PhysiologyNational Academy of Sciences of Ukraine, Kiev


Abstract

Endothelial vasoactive agents such as endothelin, angiotensin, nitric oxide and others are essential in regulation of the Na-pump functions in vascular and others tissues. In our review the intracellular mechanisms of activating and inhibition of the Na+,K+- ATPase by endothelial vasoactive agents are discussed. In the control of vascular tone and heart function as well as the regulation of the Na-pump endothelial vasoactive agents act individually or in close interaction with other physiologically active substances including the ouabain-like factor, endogenous inhibitor of the Na-pump. Some aspects ouabain-like factor physiological action are under the discussion. Recent advances in study and comprehension of intracellular mechanisms the mediating role of endothelial agents in Na-pump regulation are reviewed also.

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