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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(1): 72-76


T-[sup]786[/sup] c promoter allelicpolymorphism of endothelialno-synthase gene as genetic predictorof acute coronary syndrome

V.E.Dosenko, V.Yu.Zagoriy, Ya.M.Lutay, A.N.Parkhomenko, A.A.Moibenko

    О.О. Bogomolets Institute of Physiology National Academyof Sciences of Ukraine, Kyiv


Abstract

Frequency of promoter endothelial NO-synthase gene allelic polymorphism by using polymerase chain reaction and restriction fragment length polymorphism (RFLP-PCR) was determined in 221 patients with acute coronary syndrome (ACS) and in 83 almost healthy subjects. Data obtained indi- cate that different promoter allelic variant frequency differs significantly in patients with ACS and in control group. Correlation of normal homozygotes (Т/Т), heterozygotes (Т/С) and pathologic homozysotes (С/С) was 48%, 36% and 16% respectively in patients, and in control it was 48%, 46%, 6% (Р<0.05 by c2-test). Thus, in patients with ACS in Ukrai- nian population pathologic С/С variants of 5’- flanking region of eNOS gene were found 2.7-times more often in ACS pa- tients, than in control. This allows us to suggest, that this allelic polymorphism can be considered as one of genetic risk factors of ACS development.

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