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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(6): 118-127

Influenceof plant-originated gastroprotective and antiulcer substances on gastric mucosal repair

O.S. Zayachkivska, S.J. Konturek, D. Drozdowicz, T. Brzozowski, M.R. Gzhegotsky

    DepartmLviv National Medical University, Ukraine; Jagiellonian University College of Medicine, Cracow, Poland



Abstract

Fundamental basis of cellular and molecular mechanisms involved in mucosal injury and repair in gastrointestinal tract helps to develop new therapeutic approaches to various gut mucosal injury- related diseases. The study was aimed to as- sess the relations between plant-originated substances and their bioactivity measured in terms of antioxidant, cyto- protective and antiulceric activities and to determinate if these effects are capable of affecting the gastric mucosal lesions induced by absolute ethanol applied intragastrically. The fol- lowing plant-originated substances were considered: Solon, capsaicin, grapefruit-seed extract and amaranth. The area of gastric mucosa lesions and gastric blood flow were measured in rats with ethanol-induced lesions without (control) and with one of the tested substances without and with capsaicin dene- rvation of afferent nerves or administration of L-nitro-arginine (L-NNA), an inhibitor of nitric oxide synthase (NOS). Material/Methods: male Wistar rats, weighing 180-220 g fasted for 24 h before the study, 100% ethanol was applied ig to induced gastric lesions, whose area was determined by planimetry. Gastric blood flow was assessed using electro- lytic regional blood flowmeter. Results: All tested plant-originated substances afforded gastroprotection against ethanol-induced damage and this was accompanied by an increase in gastric microcirculation, both changes being reversed by pretreatment with neurotoxic dose of capsaicin or by pretreatment with L-NNA. Conclusions: Plant-originated substances are highly gastroprotective probably due to enhancement of the expres- sion of NOS I, NO release and an increase in gastric microcir- culation.

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