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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(6): 19-26


Influence of membranecomposition modification on cardiac and vascular reactivity

A.M. Shysh, S.M. Pivovar, T.V. Kukoba, A.V. Kotsuruba, O.O. Moobenko

    A.A.Bogomoletz Institute of Physiology, National Academy ofScience of Ukraine, Kiev.


Abstract

The work is dedicated to examination of the effect an w-3 polyunsaturated fatty acids (PUFA) on vascular and cardiac reactivity in intact animals. In experiments on isolated perfused rat hearts and isolated rings of rat aorta it was shown that reactivity in rats with modified membranes was lesser than in control animals after adding norepinephrine in raising concentrations. Use of w-3 PUFA resulted in the decrease of w-6 PUFAs (arachidonic acid (AA)) content, while w-3 PUFAs (EPA, DHA) content in cardiomyocytes membranes increased. Besides that it was shown that after w-3 PUFA enriched diet NO3- content increased in cardiac tissues and blood.

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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.