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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(6): 3-8

Electrical responses of intact aortic endothelialcells in streptozotocin-induced diabetic rats

O.I. Bondarenko, O.D. Prysyazhna, V.F. Sagach

    Bogomoletz Institute of Physiology National Academy ofSciences of Ukraine.



Abstract

The changes in electrical properties of intact aortic endothelial cells from streptozotocin-induced diabetic rats were investigated. The mean resting membrane potential of unstimulated endothelium was significantly less negative (-32.7±0.8 mV) as compared with the aged-matched control group (-41.2 ±0.9 iA). In diabetic rat aortic strips, acetylcholine (2 µM) hyperpolarized endothelial cells to -57.6±1.1 mV, whereas in control group the hyperpolarization reached - 64.4±0.9 mV. The amplitude of the hyperpolarization in diabetic rats, however, was not significantly different from the control group (24.9±1.1 mV and 23.2±0.9 mV, respectively). It was concluded that endothelial cells of diabetic rat aorta have less negative membrane potential values at rest and during acetylcholine stimulation that may partially account for the suppressed endothelium-dependent relaxation in streptozotocin-induced diabetic rats.

Full text: (PDF, in Ukrainian)

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