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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(5): 73-79


Comparative evaluation of influence of snakes venoms on the system ofhemocoagulation of intoxicated animals

Amiryan S. V.

    Yerevan State University


Abstract

The changes in some biochemical parameters of hemocoagu- lation in animals, intoxicated by venoms of three species of snakes have been investigated. The investigated venoms were: venoms of Armenian adder (Vipera raddei), Transcaucasian adder (V. lebetina) and red cobra (Naja pallidd). The results have shown, that the venoms of Transcaucasian adder and red cobra have coagulating effect. The influence of a venom of Armenian adder is expressed in general delay of process, how- ever there is an amplification of fibrinolytic activity, that al- lows us to assume a development of the DIC-syndrom under influence of this venom. Considering results received by us regarding the influence of the venom of Armenian adder on the system of hemocoagulation, and also numerous data available in the literarature, we do not exclude an opportunity of the presence of disintegrins in this venom, which could present potential therapeutical interest. This allows us to assume a necessity of further investigation of this venom with attrac- tion of the newest biochemical and biophysical methods and testing both whole venom, and its separate fractions.

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