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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(5): 50-56

Effects of fatigue on the muscle reactions to changes in the external load

Bugaychenko L.A.

    A.A.Bogomoletz Institute of Physiology, National Academy ofScience of Ukraine, Kiev



Abstract

Spreading of fatigue-related effects from active to inactive parts in the cat gastrocnemius muscle was studied. Fatiguing contractions of a part of gastrocnemius muscle were evoked through stimulation of the cut ventral root (VR) S1 with rate 50 s-1 during 20 s followed by 10 s of rest, over 10–30 min (CFS). To test activation of a non-active part of this muscle the distributed stimulation of dissected VR L7 with rate of 10 s-1 per filament was applied. After achieving by the muscle a steady-state level of isometric contraction, a quick transition to isotonic condition was produced. Transient responses of shortening and lengthening were analyzed in terms of the two- component model including the fast inertialess and slow ape- riodic components. Test duration was 12 s, time intervals between tests consisted of 3 min. CFS reduced isometric force of the tested part of muscle as well as the velocity of shortening and lengthening. The muscle lengthening had been slowing down with development of the fatigue effects; the final steady value of the muscle length in transients was reduced, while weight of the inertialess component increased. Slowing of shortening was accompanied by reduction of the final length amplitude and the time constants of aperiodic component were increased. We suppose that diffusion of metabolites from ac- tive to inactive muscle fibers was the major reason for contractility deterioration. This study was supported by the INTAS grant 01-2130.

Full text: (PDF, in Ukrainian)

References

  1. Гурфинкель В. С., Левик Ю. С. Скелетная мышца: структура и функция. – М.: Наука, 1985. – 144 с.
  2. Barclay C.J. Mechanical efficiency and fatigue of fast and slow muscle of the mouse // J. Physiol. – 1996. – 497. – P. 781–794.
  3. Burke R.E. Motor units: anatomy, physiology and functional organization. – In Handbook of physiology. The nervous system. Motor control / Ed. Brookhart J.M., Mountcastle V.B. – Bethesda, Md.: Amer. Physiol. Soc, 1981. – P. 345–422.
  4. Gordon A.M., Ridgway E.B. Cross-bridges affect both TnC structure and calcium affinity in muscle fibers // Adv. Exp. Med. Biol. – 1993. – 332. – P. 183–194.
  5. Juel C., Bangsbo J., Graham T., Saltin B. Lactate and potassium fluxes from human skeletal muscle during and after intense, dynamic, knee extensor exercise // Acta Physiol. Scand. – 1990. – 140. – P. 147–159.
  6. Kostyukov A.I. Muscle dynamics: dependence of muscle length on changes in external load // Biol. Cybern. – 1987. – 56. – P. 375–387.
  7. Kostyukov A.I., Day S., Hellstrom F. et al. Fatigue- related changes in electromyogram activity of cat gas- trocnemius during frequency-modulated efferent stimu- lation // Neurosci. – 2000. – 97. – P. 801–809.
  8. Kostyukov A.I., Hellstrцm F., Korchak O.E. et al. Fa- tigue effects in the cat gastrocnemius during frequency- modulated efferent stimulation // Ibid. – 2000. – 97. – P. 789–799.
  9. 9. Kostyukov A.I., Kalezic I., Serenko S.G. et al. Spread- ing of fatigue-related effects from active to inactive parts in the medial gastrocnemius muscle of the cat // Eur. J. Appl. Physiol. – 2002. – 86. – P. 295–307.
  10. 10. Kostyukov A.I., Korchak O.E. Length changes cat so- leus muscle under frequency-modulated distributed stimulation efferents in isotony // Neurosci. – 1998. – 82. – P. 943–955.
  11. Piazessi G., Lombardi V. A cross-bridge model that is able to explain mechanical and energetic properties of shortening muscle // Biophys. J. – 1995. – 68. – P. 1966–1979.
  12. Sjogaard G. Potassium and fatigue: the pros and cons // Acta Physiol. Scand. – 1996. – 156. – P. 257–264.
  13. Sjogaard G., McComas A.J. Role of interstitial potas- sium // Adv. Exp. Med. Biol. – 1995. – 384. – P. 69–80.
  14. West W., Hicks A., McKelvie R., O’Brien J. The relationship between plasma potassium, muscle membrane excitability and force following quadriceps fatigue // Pflug. Arch. – 1996. – 432. – P. 43–49.
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