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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(4): 142-149


Calcium entry and intracellular calcium stores in regulation ofneurotransmitter release

O.N.Verkhratsky, S.A.Fedulova

    A.A.Bogomoletz Institute of Physiology National Academy ofSciences of Ukraine, KievUniversity of Manchester, UK.


Abstract

Synaptic transmission provides the fundamental mechanisms for integrative processes in neuronal networks. Efficacy of synaptic transmission is directly controlled by the amount of neurotransmitter released into synaptic cleft. The release of the neurotransmitter, in turn, is regulated by several molecular cascades expressed in the presynaptic terminal. Activity of these cascades is regulated by the concentration of free calcium ions ([Ca2+]i) within the presynaptic terminal, and therefore an increase of [Ca2+]i in the presynaptic compartment controls neurotransmitter release. Elevation of [Ca2+]i in the presynaptic terminal results from Ca2+ entry through the plasmalemmal voltage-gated calcium channels, however Ca2+ release from the endoplasmic reticulum (ER) calcium store may also contribute towards presynaptic [Ca2+]i signals. In this review we summarize data supporting the importance of the ER Ca2+ release in regulation of neurotransmitter release.

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