Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(4): 62-72


Influence of dopamine on the activity of the brain sensory-motor cortex neuronsduring conditioned reflex

V.M.Storozhuk

    A.A.Bogomoletz Institute of Physiology National Academy ofSciences of Ukraine, Kiev.


Abstract

A changes of background and evoked activity of deep cortical layers neurons and latency of the movement in the response to the conditioned stimuli were investigated in cats chronical experiments during microelectrode iontophoretic local aplication of dopamine, its antagonists and antagonists of glutamatergic and gabaergic transmission. It was shown, that application of dopamine and others synaptically active substances near soma of pyramidal neurons moderately increased their background and evoked activity and did not sygnificantly change their latency. Application of dopamine antagonists sulpiride and SCH 23390 depressed the background and evoked impulse activity and increased the latency of neuronal reaction and conditioned movements. These effects were completely removed by the aplication of the same antagonists together with dopamine. Dopamine removed the depressing influence on the background and evoked impulse activity and latency of the conditioned reflexes evoked by application of antagonists of glutamate ionotropic and metabotropic transmission ( AP- 4 and MCPG). The same stabilized influences were evoked by the iontophoretic application of GABA antagonist bicuculline. It was concluded that effects of dopamine are connected with its local inhibitory influences on the inhibitory interneurons and their synaptic endings on soma of pyramidal neurons.

References

  1. 1 Косарева В.З. Некоторые количественные данные о структуре сигмовидной извилины коры головного мозга // Арх. анатомии, гистологии и эмбриологии. – 1968. – 54. – С. 68–77.
  2. Котляр Б.И. Овчаренко Ю.С. Пластичность реакций нейронов сенсомоторной коры на звук, сочетаемый с электрофоретической аппликацией ацетилхолина // Журн. высш. нерв. деятельности. – 1976. – 26, №6. – С. 971–977.
  3. Котляр Б. И. Пластичность нервной системы. – М.: Изд-во Моск. ун-та, 1986. – 240 с.
  4. Серков Ф.Н. Современное состояние проблемы коркового торможения //Физиол. журн. СССР. – 1989. – 35, №6. – С. 101–112.
  5. Серков Ф.Н., Гончар Ю.П., Пелевин Ю.М. Характе- ристика синаптического аппарата теменной ассоциа- тивной коры (поле 5б) мозга кошки // Нейрофи- зиология. – 1989. – 21, №2. – С.174–182.
  6. Сторожук В.М. Функциональная организация нейронов соматической коры. – К.: Наук. думка, 1974. – 270 с.
  7. Сторожук В.М. Дофаминергическая модуляция импульсной активности нейронов сенсомоторной коры при условном рефлексе // Журн. высш. нерв. деятельности. – 2004. – 54, №3. – С. 489–501.
  8. Bernardi G., Cherubini E., Marciani M.G. et al. Responses of intracelularly recorded cortical neurons of the iontophoretic application of dopamine // Brain Res. – 1982. – 245. – P 267–274.
  9. 9. Ceci A., Brambilla A., Duranti P. et al. Effects of antip- sychotic drugs and selective dopaminergic antagonists on dopamin- induced facilitatory activity in prelimbic cortical pyramidal neurons. An in vitro stude // Neuro- science. – 1999. – 93. – P 107–115.
  10. 10. Gorelova N.A., Yang C.R. Dopamine D1/D5 receptor acivation modulate a persistent sodium current in rat prefrontal cortical neurons in vitro // J. Neurophysiol. – 2000. – 84. – P 75–87.
  11. Gulledge A.T., Jaffe D.B. Multiple effects of dopam-ine on layerV pyramidal cells excitability in rat pre- frontal cortex // Ibid. – 2001. – 86, № 2. – P. 586–595.
  12. Kovelowski C.J. Shneider J.S. Chronic exposure to MPTP causes cognitive disturbances without parkinsonian motor deficits in primates // Soc. Neurisciencse. – 15. – P. 41.
  13. Lidov M.S., Goldman-Rakic P.S., Gallager D.W., Rakic P. Distribution of dopaminergic receptors in the pri- mate cerbral cortex: quntitative autoradiographic analysis using [іH]raclopride, [3H] spiperone and [іH] SCH 23390 // Neuroscience. – 1991. – 40. – P 657–671.
  14. Muly E.C., Scigeti K., Goldman-Rakic P.S. D1 receptor in interneurons of macaque prefrontal cortex: distribu- tion and subcellular localization // J. Neurosciense. – 1998. – 18. – P. 10553.
  15. Nishino H., Ono T., Muramoto K. et al. Neuronal activity in the ventral area (VTA) during motivated bar press feeding in the monkey // Brain Res. –1987. – 413. – P. 302–313.
  16. Oscarsson A., Rosen I. Short- latency projection to the cat from skin and muscle afferent in the contralateral forelimb // J. Physiol. – 1966. – 182. – P. 189–210.
  17. Sawaguchi T., Goldman-Rakic P.S. Local injection of dopamine antagonist into prefrontal cortex of monkeys induces deficit in memory-guided saccades // Soc. Neurosc. Abstr. – 1989. – 15. – P. 1156.
  18. Smiley J.F., Williams S.M., Szigeti K., Goldman-Rakic P.S. Light and electron microscopic characterisation of DA-immunoreactive axons in human cerebral cortex / /J. Comparative Neurol. – 1992. – 321. – P. 325–334.
  19. 19. Storozhuk V.M., Khorevin V.I., Rozumna N.M. et al. Dopamine modulation of activity of cat sensorimotor cortex neurons during conditioned reflexes //Neuro- science Let. – 2002. – 330. – P. 171–174.
  20. 20. Storozhuk V.M., Khorevin V.I., Rozumna N.M. et al. Dopamine modulation of glutamate metabotropic receptors in conditioned reaction of sensory motor cortex neurons of the cat // Neuroscience Let. – 2004. – 356. – P. 127–130.
  21. Vincent S.L., Khan Y., Benes F.M. Cellular collocali- zation of dopamine D1 and D2 receptors in rat medial prefrontal cortex // Synapse. – 1995. – 330. – P.112.
  22. Yang C.R, Seamans J.K., Gorelova N. Electrophy- silogical and morphological properties of layers V-VI principal pyramidal cells in rat prefrontal cortex in vitro // J. Neuroscience. – 1996. – 16. – P. 1904.
  23. Zhou F.M., Hablitz J.J. Dopamine modulation of membrane and synaptic properties of interneurons in rat cerebral cortex // J. Neurophysiology. – 1999. – 81. – P. 967–976.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.