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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(4): 62-72

Influence of dopamine on the activity of the brain sensory-motor cortex neuronsduring conditioned reflex

V.M.Storozhuk

    A.A.Bogomoletz Institute of Physiology National Academy ofSciences of Ukraine, Kiev.



Abstract

A changes of background and evoked activity of deep cortical layers neurons and latency of the movement in the response to the conditioned stimuli were investigated in cats chronical experiments during microelectrode iontophoretic local aplication of dopamine, its antagonists and antagonists of glutamatergic and gabaergic transmission. It was shown, that application of dopamine and others synaptically active substances near soma of pyramidal neurons moderately increased their background and evoked activity and did not sygnificantly change their latency. Application of dopamine antagonists sulpiride and SCH 23390 depressed the background and evoked impulse activity and increased the latency of neuronal reaction and conditioned movements. These effects were completely removed by the aplication of the same antagonists together with dopamine. Dopamine removed the depressing influence on the background and evoked impulse activity and latency of the conditioned reflexes evoked by application of antagonists of glutamate ionotropic and metabotropic transmission ( AP- 4 and MCPG). The same stabilized influences were evoked by the iontophoretic application of GABA antagonist bicuculline. It was concluded that effects of dopamine are connected with its local inhibitory influences on the inhibitory interneurons and their synaptic endings on soma of pyramidal neurons.

Full text: (PDF, in Ukrainian)

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