Fiziologichnyi Zhurnal

The complex processing and integration of signals observed in neurons are facilitated by the diverse range of gating properties of the ion channels in this cell type, particularly the voltage- gated K+ channels (KV). A distinctive combination of K+ channels endows neurons with a broad repertoire of excitable properties and allows each neuron to respond in a specific manner to a given input at a given time. The properties of many K+ channels can be modulated by second messenger pathways activated by neurotransmitters and other stimuli. K+ channels are among the most frequent targets of the actions of several signalling systems.

Full text: (PDF, in Ukrainian)

Aldrich R.W., Getting P.A., Thompson S.H. Mecha- nisms of frequency dependent broadening of molluscan neurone soma spikes // J. Physiol. – 1979. –291. – P.531–544.
Armstrong C.M., Hille B. Voltage gated ion channels and electrical excitability // Ibid. – 1998. – 20. – P. 371–380.
Baukrowitz T., Yellen G. Modulation of K⁺ current by frequency and external [K⁺]: a tale of two inactivation mechanisms // Neuron. – 1995. – 15. – P. 951–960.
Breitwieser G.E. Mechanisms of K⁺ channel regulation // J. Membrane Biol. – 1996. – 152. – P. 1–11.
Greene L.A., Tischler A.S. PC12 pheochromocytoma cultures in neurobiological reseach // Adv. Cell. Nuerobiol. – 1982. – 3. – P. 373–414.
Karschin A. G–protein regulation of inwardly rectifying K⁺ channels // News Physiol. Sci. – 1999. – 14. – P. 215–220.
Loboda A., Melishchuk A., Armstrong C. Dilated and defunct K channels in the absence of K+ // Biophys. J. – 2001. – 80. – P. 2704–2714.
Salkoff L., Baker K., Butler A. An essential “set” of K⁺ channels conserved in flies, mice and humans // Trends in Neurosciences – 1995. – 18. – P. 161–166.
9. Sherrington C.S. The Integrative Action of the Nervous System. – New Yfwen, NJ: Yale University Press, 1906.
10. Toro L., Wallner M., Meera P., Tanaka Y. Maxi-K_ca,a unique member of the voltage-gated K channel super- family // News Physiol. Sci. – 1998. – 13. – P. 112–117.
Whim M.D., Kaczmarek L.K. Heterologous expres- sion of the K_V 3.1 potassium channel eliminates spike broadening and the induction of a depolarizing after- potential in the peptidergic bag cell neurons // J. Neurosci. – 1998. – 18. – P. 9181–9191.

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Information

Content of journals

Fiziol. Zh. 2004; 50(4): 57-61

Changes in extracellular k+ concentrationmodulate properties of voltage-dependent k+ conductance in pc-12 cells

Abstract

References

ISSN 2522-9028 (Print) ISSN 2522-9036 (Online) DOI: https://doi.org/10.15407/fz