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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2003; 49(6): 38-42


Renal mechanisms of protective potassium effectunder essential hypertension

M.V. Kryshtal, T.V. Kukoba, O.O. Moybenko

    A. Bogomoletz National Medical University, *A. BogomoletzInstitute of Physiology, National Academy of Sciensec ofUkraine, Kiev


Abstract

In experiments on nonlinear rats, the renal functions were in- vestigated at aqueous diuresis induced by intragastric admin- istration of sodium potassium, potassium hydrocarbonate (20 mM/kg ), and potassium succinate (10 mM/kg). We have found that the load by potassium raised glomerular filtration rate and sharply increased excretion of not only K+ but also Na+ and Cl- with urine, that led to hyponatremia and hypochloremia following hyperkalemia. In addition, the intracellular con- centration of K+ increased more than extracellular one, especially after administrating КНСО3 and potassium succinate. It promoted potassium efflux from cells by concen- tration gradient, hyperpolarization of cellular membrane and vascular smooth muscle relaxation. Thus, these data explain renal mechanisms of a known protective effect of potassium at essential hypertension.

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