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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2000; 46(4): 17-23

The Investigationof Vasomotion Effects of New Fluorine-Contening Openers Atp-SensitivePotassium Channels

Strutinskii R. B., Moibenko A. A., Yagupolskii L. M

    A.A.Bogomoletz Institute of PhysiologyNational Academy of Science of Ukraine, Kiev



Abstract

The influence of new fluorine-containing activators of K+ channels on the vascular tone was investigated in vitro experiments on the guinea pig aorta. We exerted the identification of mechanisms of the action of these substances using the well-known ATP-sensitive K+ channel inhibitor – glibenclamid – and showed their dose-effect correlation. It was shown that new fluorine-containing activators of K+ channels – PF -5 and PF-10 – are powerful vasodilator substances and PF-5 in concentration more than 0.1 mM exerts a distort of vascular reaction on the vasoconstriction.

Full text: (PDF, in Ukrainian)

References

  1. Пат. України, №17071А від 18.03.1997. N-1,2,2,-триметилпропіл-N??-ціано-N?-арілгу-анідини з фторвмісними замісниками в арільному ядрі, які проявляють гіпотензивніта кардіотонінні дії / Клебанов Б.М., Малетіна І.І., Петко К.І., Шаваран С.С.,Ягупольський Л.М. // Винахідник України. — 1997.
  2. Adeagbo A.S., Malik K.U. Contribution of K+ channels to arachidonik acid-inducedendothelium-dependent vasodilation in rat isolated perfused mesenteric arteries //J. Pharmacol. Exp. Ther.— 1991. — 258, № 2. — P.452-458.
  3. Brady P.A., Alekseev A.E., Andre Terzic. Operative condition-dependent response ofcardiac ATP-sensitive K+ channels toward sulfonylureas // Circulat. Res.—1998. —82. — P.272-278.
  4. Benndorf K., Thierfelder S., Doepner B., Gebhardt C., Hirche H. Role of cardiac KATPchannels during anoxia and ischemia // News Physiol. Sci.— 1997.— 12. — P.78-83.
  5. Bhatnagar A., Bolli R. Modulation of KATP channels to protect the ischemic miocardium:Clinical implications // Exp. Clin. Cardiol.—1999.— 4. — №1. — P.20-22.
  6. Cavero I., Djellas Y.,Guillon J-M. Ischemic miocardial cell protection conferred by theopening of ATP-sensitive potassium channels // Cardiovasc. Drags Ther. — 1995. —9, № 2. — P.245-255.
  7. Chi I., Uprichard A.S., Lucchesi D.R. Profibrillatory actions of pinacidil in a consciouscanine model of sudden coronary death // J. Cardiovasc. Pharmacol. — 1990. —15. — P.452-464.
  8. Cyrys S., and J. Daut. The sensitivity of coronary vascular tone to glibenclamide: astudy in the isolated perfused guinea pig heart // Cardiovasc. Res.— 1994. — 28. —P.888-893.
  9. 9. D’Alonzo A.J., Zhu J.I. Darbenzio R.B.,Dorso C.R., Groser G.J. Proarrhythmic effectsof pinacidil are partially mediated through enchancement of catecholamine release inisolated perfused guinea-pig heart // J. Mol. Cell Cardiol. — 1998. — 30. — P.415-423.
  10. 10. Dart C., Standen N.B. Adenosine-activated potassium current in smooth muscle cellsisolated from the pig coronary artery // J. Physiol (Lond). — 1993.— 471. — P.767-786.
  11. Daut J., Maier-Rudolph W.,von Beckerath N., Mehrke G., Gunther K., Goedel-Meinen L. Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassiumchannels // Science.— 1990. — 247. — P.1341-1344.
  12. Dunne M.J., Illot M.C., Peterson O.H. Interaction of diazoxide, tolbutamide andATP4- on nucleotide-dependent K+ channels in an insulin-secreting cell line // J. Membr.Biol. — 1987. — 99. — P.215-224.
  13. Edwards G., Weston A.,N. Pharmacology of the potassium channel openers //Cardiovasc. Drags Ther. — 1995. — 9, № 2. — P.185-193.
  14. Findlay I. Inhibition of ATP-sensitive K+ channels in cardiac muscle by the sulfonylureadrag glibenclamide // J. Pharmacol. Exp. Ther.—1992. — 261. — P.540-545.
  15. Garrino M.J., Plant T.D., Henquin J.C. Effects of putative activators of K+ channelsin mouse pancreatic b-cell // Brit. J. Pharmacol. — 1989. — 98. — P.957-965.
  16. Hamada E., Takikawa R., Ito H.,Iguchi M., Terano A., Sugimoto T., Kurachi Y.Glibenclamide specifically blocks ATP-sensitive K+ channel current in atrial myocytesof guinea pig heart // Jpn. J. Pharmacol. — 1990. — 54. — P.473-477.
  17. Hiraoka M., Furukawa T. Functional modulation of cardiac ATP-sensitive K+ channels.// News Physiol. Sci. — 1998. — 13. — P.131-137.
  18. Komaru T., Lamping K.G., Eastham C.L., Dellsperger K.C. Role of ATP-sensitivepotassium channels in coronary microvascular autoregulatory responses // Circulat.Res. — 1991. — 69. — P.1146-1151.
  19. 19. Murphy M.E., Brayden J.E. Nitric oxide hiperpolarizes rabbit mesenteric arterries viaATP-sensitive potassium channels // J. Physiol. — 1995. — 486, №1. — P.47-58.
  20. 20. Nelson M.T., Quayle J.M. Physiological roles and properties of potassium channels inarterial smooth muscle // Amer. J. Physiol.—1995. — 268. — P.C799-C822.
  21. Nichols C.G., Lederer W.J. Adenosine triphosphate-sensitive potassium channels inthe cardiovascular system // Ibid. — 1991. — 261. — P.H1675-H1686.
  22. Noma A. ATP-regulated K+ channels in cardiac muscle // Nature. — 1983. — 305. —P.147-148.
  23. Panten U., Schwanstecher M., Schwanstecher C. Sulfonylurea receptors and mechanismof sulfonylurea action // Exp. Clin. Endocrinol. Diabetes. — 1996. — 104. — P.1-9.
  24. Pavingerova T., Loekeboe J.E., Sundset R., Ytrehus K. Preconditioning against con-tractile dysfunction in guinea pig papilary muscle depends on the opening of KATP-sen-sitive channels // Exp. Clin. Cardiol. — 1998. — 3. — №3. — P.184-187.
  25. Petersen H.J., Kaergaard-Nielsen C., Arrigoni-Martelli E. Synthesis and hypotensiveactivity of N-alkyl-N??-cyano-N??-pyridylguanidines // J. Med. Chem. — 1978. — 21.—P.773-781.
  26. Quayle J.M., Nelson M.T., Standen N.B. ATP-sensitive and inwardly rectifyingpotassium channels in smooth muscle // Physiol. Rev. — 1997. — 77. — №4. —P.1165-1232.
  27. Schultz Jo El J., Zhenhai Yao, Icilio Cavero, Garrett J. Gross. Glibenclamide-inducedblockade of ischmic preconditioning is time dependent in intact rat heart // Amer.J. Physiol. — 1997. — 272, № 41.—P.H2607-H2615.
  28. Shigematsu S., Toshiaki S., Takaka A., Tetsunori S., Makoto A. Pharmacologicalevidence for the persistent activation of ATP-sensitive potassium channels in earlyphase of reperfusion and its protective role against myocardial stunning // Circula-tion. — 1995. — 92. — P.2266-2275.
  29. 29. Sturgess N.C., Kozlowski R.Z., Carrington C.A., Hales C.N., Ashford M.L.J. Effectsof sulfonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels inan insulin-secreting cell line // Brit. J. Pharmacol. — 1988. — 95. — P.83-94.
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