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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2000; 46(4): 17-23


The Investigationof Vasomotion Effects of New Fluorine-Contening Openers Atp-SensitivePotassium Channels

Strutinskii R. B., Moibenko A. A., Yagupolskii L. M

    A.A.Bogomoletz Institute of PhysiologyNational Academy of Science of Ukraine, Kiev


Abstract

The influence of new fluorine-containing activators of K+ channels on the vascular tone was investigated in vitro experiments on the guinea pig aorta. We exerted the identification of mechanisms of the action of these substances using the well-known ATP-sensitive K+ channel inhibitor – glibenclamid – and showed their dose-effect correlation. It was shown that new fluorine-containing activators of K+ channels – PF -5 and PF-10 – are powerful vasodilator substances and PF-5 in concentration more than 0.1 mM exerts a distort of vascular reaction on the vasoconstriction.

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