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The influence of glycolysis and blockade ofmyoendothelial gap junctions on contractile responses of pulmonary artery and aorta in ratsunder hypoxia
I.V. Kizub, A.I. Soloviev, A.A. Moibenko, A.V. Stefanov
Institute of Pharmacology and Toxicology Academy of Medi-cal Sciences of Ukraine, Kiev,A.A. Bogomoletz Institute of Physiology National Academy ofSciences of Ukraine, Kiev
Abstract
The effects of blockade of glycolysis on the contractile activity
of isolated vascular rings of both the pulmonary artery
and. the thoracic aorta were studied under hypoxia in intact,
denuded vessels and those with blocked myoendothelial electrical
coupling. The blockade of glycolysis led to a reversion
of a hypoxic contraction in the pulmonary artery but had no
effect on hypoxic dilatation of the aorta. Hypoxic constriction
of the pulmonary artery was abolished after denudation
and stayed unchanged at the following blockade of glycolysis.
Moreover, blockade of glycolysis had no effect on the
hypoxic responses of the pulmonary artery after blockade of
the myoendothelial gap junctions. The data suggest that hypoxic
contraction of the pulmonary artery is endothelium-dependent,
in contrast to the hypoxic dilatation of the aorta.
It is likely that glycolysis in endothelial cells and myoendothelial
gap junctions contribute to hypoxic pulmonary vasoconstriction
due to formation and conduction the depolarizing electrical signals from endothelial cells to smooth muscles
causing their contraction under hypoxia.
References
- Базилюк О.В., Берштейн С.А., Соловьев А.И. Роль эндотелия в развитии сократительных реакций сосудистых гладких мышц при снижении их оксигенации // Бюл. эксперим. биологии и медицины. 1986. – 101, №6. – С.134 – 141.
- Гуревич М.И., Берштейн С.А., Соловьев А.И. Дефицит кислорода в тканях и их кровоснабжение // Успехи физиол. наук. – 1981. – 12, №4. – С.77 – 98.
- Соловьев А.И., Берштейн С.А. Влияние блокады гликолиза в сосудистой стенке на фазную активность гладких мышц // Бюл. эксперим. биологии и медицины. – 1982. – 94, №8. – С.11 – 13.
- Соловьев А.И. Особенности реагирования сосудистых гладких мышц на кислород при блокаде гликолиза в сосудистой стенке // Физиол. журн. – 1984. – 30, №6. – С.733 – 736.
- Соловьев А.И., Стефанов А.В. Механизмы изменения кальциевой проводимости сарколеммы гладкомышечных клеток сосудов при гипоксии // Физиол. журн. СССР. – 1985. – 71, №12. – С.1560 – 1567.
- Emerson G.G., Segal S.S., Electrical coupling between endothelial cells and smooth muscle cells in hamster feed
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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