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Investigation of coronary vascular responses in non-ischemic myocardium at experimental acute ischemia-reperfusion
A.A.Moibenko, M.Ya.Yuzkiv, V.I.Azarov
A.A.Bogomoletz Institute of Physioligy, Kiev
Abstract
The aim of this study was to investigate coronary vascular
responses, particularly NO-dependent, in the non-ischemic
miocardium during local acute myocardial ischemia/reperfusion.
The experiments were performed on the dogs with closed
chest. Occlusion of a branch of the coronary artery resulted
in a dilatation of the coronary vessels within the intact part of
the myocardium. Neither inhibition of prostanoid production
and KATP-channels, nor administration of atropine sulfate
and dissection of the vagus nerve altered coronary dilatation
within the non-ischemic myocardium. Whereas inhibition
of NOS by L-NNA (50 mg/kg) completely changed it after
coronary occlusion, furthemore coronary resistance temporally
increased. Thus, the most reliable mechanism of that
response was NO-dependent.
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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