Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2003; 49(3): 144-149


Carotid body hemoreceptors and animal adaptive reac-tions

N.A.Agadjanyan, A.I.Elfimov, L.V.Shevchenko

    Russian Peoples` Frendship University, Moskow


Abstract

After surgical denervation of sinocarotid reflexogenic zones and bilateral glomectomy in white laboratory rats oxygen consumption, rectal temperature, rate of cardial contractions and thermoregulatory activity of skeletal muscles display authentic increase. Glomectomy results in decreasing calorigecic effect of noradrenaline. Compensatory increase of thermoregulatory activity of sceletal muscles in response to beta-adrenogenic blocade with inderal in post-glomectomic animals is authentically less, than before inactivation of carotid receptors. In animals after carotid glomectomy resistance to acute hypoxia is clearly reduced. True reduction of number of erythrocytes, of hemoglobin concentration, of hematocrite parameter in post glomectic animals was found, which indicates anemisation phenomena. It was found that glomectomy after adaptation of animals in the mountains of Tien Shan at the height of 3200 m during 30 days didn’t substancively change resistance to acute hypoxia. Resistance to acute hypoxia of animals living on mountains (susliks, marmots) is higer than of animals living on plains. Glomectomy performed on animals living on mountain resulted in an insignificant decrease in resistance to acute hypoxia. Resistance to acute hypoxia in postglomectic animals was found to be directly linked with absolute amount of hemoglobin concentration and erythrocyte number. In that way denervation of sinocarotid reflexogenic zones and bilateral glomectomy is an adequate method of comparative research of functions regulation mechanism during formation of adaptive responces in animals in dependence of various factors of external environment in norm, as well, as in pathology.

References

  1. Агаджанян Н.А., Елфимов А.И. О роли хеморе цепторов в адаптации организма к гипоксии // Успехи физиол. наук. – 1977. – 8,N1. – С.44 – 55.
  2. Агаджанян Н.А., Елфимов А.И. Функции организма в условиях гипоксии и гиперкапнии. – М.: Медицина,1986. – 272 с.
  3. Аничков С.В., Беленький М.Л. Фармакология химиорецепторов каротидного клубочка. – Л.: Медгиз,1962. – 200 с.
  4. Анохин П.К. Теория функциональной системы // Успехи физиол. наук. – 1970. – 1. – C.19 – 54.
  5. Бреслав И.С. Дыхательные рефлексы с хеморецепторов. – В кн.: Физиология дыхания / Ред. Л.Л.Шик. – Л., Наука, 1973. – С.165 – 168.
  6. Елфимов А.И. Методика гломусэктомии у белых крыс. – В кн.: Актуальные вопросы космической биологии и медицины. – М., 1971. – С. 109 – 110.
  7. Мойбенко А.А. Кардиогенные рефлексы и их роль в регуляции кровообращения. – К., Наук. думка,1979. – 263 с.
  8. Сафонов В.А., Ефимов В.Н., Чумаченко А.А. Нейро-физиология дыхания. – М.: Медицина, 1980. – 223 с.
  9. 9. Шевченко Л.В., Елфимов А.И. Суточная динамика показателей красной крови у крыс после каротидной гломэктомии //Бюл.эксперим.биологии и медицины. – 1992. – 113, № 3. – С.232 – 233.
  10. 10. Шевченко Л.В., Елфимов А.И. Влияние каротидной гломэктомии на показатели красной крови у крыс в зависимости от индивидуальной устойчивости к гипоксии // Там же. – 1996. – 122, № 7. – С.12 – 13.
  11. Шевченко Л.В., Елфимов А.И. Воздействие измененной газовой среды и температуры на животных с сахарным диабетом // Там же. – 1998. – 126, № 9. – С.248 – 252.
  12. Юматов Е.А. Функциональная система поддержания оптимальных величин дыхательных показателей рН, рСО2, рО2 организма. – В кн.: Основы физиологии функциональных систем. – М.: Медицина, 1983. – С.57 – 76.
  13. Biscoe T.J. Carotid Body: Structure and Function // Physiol.Rev. – 1971. – 51, № 3. – P.427 – 495.
  14. Bisgard G.E., Vogel J.H.K. Hypoventilation and pulmonary hyprtension in calves after carotid body excision // J.Appl. Physiol. – 1971. – 31, № 3. – P.431 – 437.
  15. Dwinell M.R., Huey K.A., Powell F.L. Chronic hypoxia induces changes in the central nervous system processing of arterial chemoreceptor input // Adv. Exp. Med. Biol. – 2000. - 475. – P 477 – 484.
  16. Hanson M.A. Role of chemoreceptors in effects of chronic hypoxia // Comp. Biochem. Physiol. A. Mol. Integr. Physiol. – 1998. – 119, № 3. – P 695 – 703. 17. Ledderhos C., Gross V., Cowley A.W. Pharmacological stimulation of arterial chemoreceptors in conscious rats

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.