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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2000; 46(4): 3-7

Some Effector Reactions of Immune Systemunder the Influence of Nonpeptide Spleen Facto

Tronko М. D., Bykova L. M., Boyko M. G., Synelnykova G. L.,Olyinik B. V

    V. P. Komissarenko Institute of Endocrinology and Metabolism,Academy of Medical Sciences of Ukraine, Kiev



Abstract

The influence of low molecular nonpeptide preparation splenosid obtained from bovine spleen on the cytotoxic activity of natural killers, reaction of complement binding and the immune responsibility was investigated. It was shown that even single treatment of rats with splenosid in a dose of 300 mkg/100 g in 48 hours stimulates the cytolytic activity of splenocytes on target cells (sheep erythrocytes). The same results were obtained in vitro. The treatment of quinea pigs with splenosid reduces the complement activity in serum. This preparation depresses the splenocyte immunoreactivity in sensibilyzed mice in a dose — dependent manner. The data obtained complete our knowleges about biological activity of splenosid.

Full text: (PDF, in Ukrainian)

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