Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2003; 49(3): 63-69

Peculiarities of the reaction of respiration tohypoxia in aging

O.V.Korkushko, V.Yu.Lishnevskaya, V.P.Chizhova, T.V.Ruhlyada, G.V.Duzhak

    Institute of gerontology AMS of Ukraine, Kie



Abstract

The purpose of the research was to investigate the peculiarities of ventilatory reaction to hypoxia with the elderly and old people. 27 practically healthy young (20-35 years), 24 elderly (60-74 years) and old (older 74 years) people were examined. The influence of hypoxia on the gas exchange was investigated during the respiration of gas mixtures with 17 % and 12,5 % of oxygen content (during 12 minutes), that corresponds to 1500 m and 4000 m above sea level. The parameters of ventilating function of the lung were determined on the spirograf СГ-1М. Oxygen tension in arterial blood (paO2) was determined with the device «AVL» by «OMNI» (Austria). The curves of ventilating dependence on paO2 for the young and old people are plotted using the mathematical model. It was shown, that with aging the “steepness” of curve’s dependence on the ventilatory answer from the degree of hypoxemia decreases, that testifies to the decrease of chemoreflex sensitivity.

Full text: (PDF, in Ukrainian)

References

  1. Агаджанян Н.А., Елфимов А.И. Функции организма в условиях гипоксии и гиперкапнии. – М.: Медицина, 1986. – 272 с.
  2. Амосов Н.М., Палец Б.Л., Агапов Б.Г. и др. Теоретические исследования физиологических систем. Математическое моделирование. ? К.: Наук. думка, 1977. ? 245 с.
  3. Гипоксия. Адаптация, патогенез, клиника. – СПб, ООО “ЭЛБИ-СПб”, 200. – 384 с.
  4. Дудел Д., Циммерман М., Шмидт Р. и др. Физиология человека. ? М.: Мир, 1985. – 240 с.
  5. Коркушко О.В., Джемайло В.И. Возрастные особенности аппарата внешнего дыхания. - В кн.: Старение и физиологические системы организма. ?К., 1969. ? С. 253 ? 267.
  6. Коркушко О.В., Иванов Л.А. Гипоксия и старение. ?К., 1980. – 276 с.
  7. Коркушко О.В., Иванов Л.А., Джемайло В.И. Функциональная диагностика системы внешнего дыхания в пожилом и старческом возрасте // Метод.письмо. – К., 1971, ? 15 с.
  8. Милсум Дж. Анализ биологических систем управления. ? М : Мир, 1968. ? 501 с.
  9. 9. Руководство по клинической физиологии дыхания /Под ред. Л.Л.Шика, Н.Н.Канаева. ? Л.:Медицина,1980. ? 376 с.
  10. 10. Bisgard G.E. The role of arterial chemoreceptors in ventilatory acclimatization to hypoxia // Adv. Exp. Med Biol. –1994. – 360. – P. 109 ? 122.
  11. Bisgard G.E. Carotid body mechanisms in acclimatization to hypoxia // Respir. Physiol. – 2000. – 121. – P. 237 ? 246.
  12. Kolesnikova E.E., Serebrovskaya T.V. Age-related peculiarities of catecholamines exchange and ventilatory responses to hypoxia and hypercapnia under adaptation to intermittent hypoxia // Arkhiv Clin. and Exper. Med. ?2001. ? 10(2). – P. 165 ? 166.
  13. Lukyanova L.D. Mechanisms of the organism resistance to hypoxia // Hypoxia Medical J. ? 1996. ? 4 (2). – P. 42.
  14. Serebrovskaia T.V. Sensitivity to a hypoxic and hypercapnic stimulus as a reflection of the individual reactivity of the human body // Patol Fiziol Eksp Ter. – 1985. – 5. – P. 65 ? 69.
  15. Serebrovskaya T.V. Comparison of respiratory and circulatory human responses to progressive hypoxia and hypercapnia // Respiration. – 1992. ? 59(1). P. ? 35 ? 41.
  16. Weil J.W., Byrne-Quinn E., Sodal I.E., et al. Hypoxic ventilatory drive in normal man //J. Clin. Invest. ? 1970. – 49. P. ? 1061 ? 1072.
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.