The influence of hericium erinaceusextract on myelination process in vitro
E.V.kolotushkina, M.G.moldavan, K.yU.voronin, G.G.skibo
A.A.Bogomoletz Institute of Physiology National Academy ofSciences, Kiev
Myelin sheathes, wrapping axons, perform the following important
functions: support, protection, feeding and isolation.
Injury of myelin compact structure leads to an impairment andsevere illness of the nerve system. Exact mechanisms underlying
the myelination process and myelin sheaths damage have
not established yet. Therefore search for substances, which
provide regulatory and protective effects on the normal myelination
as well as stimulating action on the remyelination after
myelin damage, is of special interest. Recently it was shown
that extract from mushroom Hericium erinaceus had activating
action on the nerve tissue. So the aim of the present work
was to study an influence of an extract from H. erinaceus on
the cerebellar cells and the process of myelination in vitro.
Obtained data revealed the normal growth of the nerve and glial
cells with extract at cultivating. No pathologic or toxic action
of the extract has been found. The cell ultrastructure was intact
and similar to that observed in vivo. The process of myelination
in the presence of the extract began earlier as compared to
controls and was characterised by a higher rate. Thus, extract
of H. erinaceus promoted normal development of cultivated
cerebellar cells and demonstrated a regulatory effect on the
process of myelin genesis process in vitro.
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