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The influence of kynurenic acid on the catecholamine contents in brain of rats withdifferent seizure susceptibility
L.D.Popova
Kharkov State Medical University
Abstract
The influence of kynurenic acid on the catecholamine contents
in brain of rats with different seizure susceptibility was studied.
In animals with high seizure susceptibility the decrease in
norepinephrine content and the increase in the coefficient ratio
between dopamine and norepinephrine have been found in the
most of the regions investigated. Kynurenic acid caused considerable changes in the contents of catecholamines and their
precursor in the brain of both groups of animals. The influence
of kynurenate on the norepinephrine content was especially
significant. The results of a comparison of the absolute contents
of catecholamines, as wel las the ratio between the contents of
a precursor and the transmitter and the levels of the transmitter
in the appropriate nervous terminals are the base to suggest
that kynurenic acid enhances the conversion of tyrosine into
dopamine, increases its transport to nervous terminals, and
decreases the noradrenergic transmission.
References
- Захария Б.А. Предрасположенность организма к эпилептическим припадкам. – К.: Здоров’я, 1974. – 200 с.
- Комиссаров И.Б., Абрамец И.И. Модуляция эффективности межнейронных связей биорегуляторами и фармакологическими средствами. – Донецк, 1994. –160 с.
- Попова Л.Д. Особенности обмена триптофана у животных с высокой и низкой аудиогенной судорожной готовностью: Автореф. дис. … канд. биол. наук. –Харьков, 1986. – 25 с.
- Сергиенко Н.Г., Грищенко В.И., Логинова Г.А. Биогенные моноамины и возбудимость головного мозга. –К.: Наук. думка, 1992. – 148 с.
- Barone D., Palma V., de Bartolomeis A. et al. Dopaminergic regulation of epileptic activity// Neurochem. Int. – 1992. –№ 20. – P. 245 – 249.
- Carla V., Lombardi G., Beni M. еt al. Identification and measurement of kynurenic acid in the rat brain and other organs// Anal. Biochem. – 1988. – 169. – P. 89 – 94.
- Dale W.E., Dung Y., Amiridze M., Brown O.P. Evidence that kynurenine pathway metabolites mediate hyperbaric –reduced convulsions// Toxicol. Lett. – 2000. – 117,№ 1 – 2. – P. 37 – 43.
- Endo J., Ogura J. Separation of biogenic amines in rat brain on a phosphorylated cellulose column// Eur. J. Pharmacol. –1973. – 21. – P. 293 – 298.
- 9. Fukui S., Schwarcz R., Rapoport S.I. et al. Blood-brain barrier transport of kynurenines: implication for brain synthesis and metabolism// J. Neurochem. – 1991. – 56, № 6. –P. 2007 – 2017.
- 6 № ,84 .Т ,2002 ,.нруж .лоізіФ 9848-1020 NSSI45
- 10. George B., Kulkarni S.K. Dopaminergic modulation of lithium/ pilocarpine – induced status epilepticus in rats//Methods Find. Exp. Clin. Pharmacol. – 1997. – 19, № 7.P. 481 – 486.
- Joel K., Lamdani-Itkin H., Sokolovsky M. The glycine site of the N-methyl-D-aspartate receptor channel: differences between the binding of HA-966 and of 7-chlorokynurenic acid// J. Neurochem. – 1990. – 54, № 5. –P. 1576 – 1583.
- Lapin I.P. Kynurenines and seizures// Epilepsia. – 1981. –22. – P. 257 – 265.
- Lee S., Schwarcz R. Excitotoxic injury stimulates pro-druginduced chlorokynurenate formation in the rat striatum in vivo// Neurosci. Lett. – 2001. – 304, № 3. – P. 185 – 188.
- Martel J. C., Chopin P., Marien M. Drug treatments to reduce excitotoxicity in vivo: a potential for alpha-2-adrenoreceptor antagonists// Amino Acids. – 2000. – 10, № 1. –P. 239 – 252.
- Obrenovitch T.P., Urenjak J. In vivo assesment of kynurenate neuroprotective potency and quinolinate excitotoxicity// Ibid. – P. 299 –309.
- Schlupt M., Liichtensteiger W., Langemann H. A fluorimetric micromethod for the simultaneous determination of serotonin, noradrenaline and dopamine in milligram amounts of brain tissue// Biochem. Pharmacol. – 23. –P. 2437 – 2446.
- St’astny F., Skultetyova, Pliss L., Jezova D. Quinolinic acid enhances permeability of rat brain microvessels to plasma albumin// Brain Res. Bull. – 2000. – 53, №4. –P. 415 – 420.
- Stone T.W. Inhibitors of the kynurenine pathway// Eur. J. Med. Chem. – 2000. – 35, № 2. – P. 179 – 186.
- 19. Stone T.W. Kynurenines in the CNS: from endogenous obscurity to therapeutic importance// Prog. Neurobiol. –2001. – 64, № 2. – P. 185 – 218.
- 20. Turski W., Nakamura M., Todd W.P. et al. Identification and quantification of kynurenic acid in human brain tissue/ / Brain Res. – 1988. – 454. – P. 164 – 169.
- Turski W.A., Gramsbergen J.B.P., Traitler H., Schwarcz R. Rat brain slices roduce and liberate kynurenic acid upon exposure to L-kynurenine// J. Biochem. – 1989. – 52. – P.1629 – 1636.
- Van Q.S., Dailly J.W., Steenbergen J.L., Jobe P.C. Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy –prone rats (GEPRs); a microinjection study// Brain Res. –1998. – 780, № 2. – P. 199 – 209.
- Vezzani A., Stasi M.A., Wu H.G. et al. Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic in rats with altered blood-brain barrier permeability// Exp. Neurol. – 1989. – 106, №1. – P.90 – 98.
- Wu H.G., Guidetti P., Goodman J.H. et al. Kynurenergic manipulations influence excitatory synaptic function and ecitotoxic vulnerability in the rat hippocampus in vivo//Neuroscience. – 2000. – 97, №2. – P. 243 – 251.
- Yourick D.L., La Placa M.C., Meyerhoff J.L. Norepinephrine – stimulated phosphatidyl inositol metabolism in genetically epilepsy – prone and kindled rats // Brain Res. – 1991. – 651, № 1-2. – P. 315 – 318.
- Zhu S.G., Mc Geer E.G., Mc Geer F.L. Effect of MK-801, kynurenate, glycine, dextrophan and 4-acetylpyridine on striatal toxicity of quinolinate// Ibid. – 1989. – 481,№ 2. – Р. 356 – 360.
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