Change in contractile vascularfunctionin arterial hypertension of different genesis and its correction with phosphsatidylcholineliposomes
A.I. Soloviev, S.M. Tishkin, A.S. Khromov, A.V. Stefanov
Institute of Pharmacology & Toxicology, Academy of MedicalSciences, Kiev
Abstract
We examined the effects of phosphatidylcholine liposomes
(PCL) upon the contractile vascular dysfunction in spontaneously hypertensive rats (SHR) and γ-irradiated (60Co,
6 Gy) rats and rabbits. A significant impairment of endothelium-dependent relaxation was evident in both SHR and
irradiated animals. An important novel finding of these experiments is that the impairment was mainly due to the loss of
NO-dependent component of relaxation, with the component
of relaxation mediated by EDHF being preserved. PCL were
found to restore endothelium-dependent relaxation in both
SHR and the irradiated vascular tissues. It is important to
note that irradiated animals exhibited distinct and sustained
signs of hypertension (blood pressure (BP) increased from
122 ±8 to 185±6 mm Hg). Being administered in a single dose
of 30 mg/kg, 1 h after irradiation, PCL prevented hypertension
development in an early post-irradiated period (9 days). At a
later post-irradiated period (6 months), PCL in the single
dose lost such a protective effect. Single administration of
PCL in SHR led to a transient decrease in BP, but their
repeated daily administration caused a persistent decrease in
BP up to its normalization as early as in 4 days. These results
suggest that PCL possess hypotensive activities due to their
ability to normalize endothelial function.
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