Myokines are signaling molecules produced by skeletal muscle in response to exercise and exert a wide range of physiological effects in various organs and tissues. They play a key role in regulating metabolic processes, modulating the immune response, and maintaining homeostasis of the body. The relationship between the level of physical activity and the production of myokines determines their therapeutic potential in maintaining cardiovascular and nervous system health. Studies also show that certain types of physical activity can activate different myokines, which allows for targeted effects on certain aspects of metabolic health. Studies indicate significant potential for myokines as therapeutic targets for improving health and preventing chronic diseases, especially in the context of cardiometabolic disorders, including hypertension, atherosclerosis, and heart failure.