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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2025; 71(3): 67-72

ACUTE PHASE PROTEINS AS BIOMARKERS OF INFLAMMATION UNDER THERMAL INJURY MODELING CONDITIONS

I.G. Litovka1, M.O. Zavgorodniy1, S. Magomedov2, P.K. Tsapenko1, N.M. Bobok3, R.V. Yanko1

  1. O.O. Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv
  2. SU “Institute of Traumatology and Orthopedics, NAMS of Ukraine”, Kyiv, Ukraine
  3. INSTITUM AG, Zug, Switzerland
DOI: https://doi.org/10.15407/fz71.03.067


Abstract

Determination of the concentration of acute phase proteins (AFPs) is due to their key role in the cascade of nonspecific defense reactions in thermal injuries. A feature of most AFPs is nonspecificity and high correlation of blood concentration with the activity of the pathological process. Studying biochemical markers in the early post-burn period, it was found that a pronounced systemic inflammatory response after thermal injury occurred between the 3rd and 9th day. At the same time, haptoglobin and ceruloplasmin act as faster acute phase proteins. The concentration of these proteins in the blood serum of rats increased and reached maximum values on the 3rd day after burn injury, which makes them an effective marker for detecting early inflammatory reactions and infectious complications. The dynamics of changes in the level of C-reactive protein in the blood serum demonstrated the highest correlation with the activity of the infectious process, which proves its high efficiency for detecting inflammatory processes of varying severity, choosing adequate treatment and predicting the course of the disease. The results obtained can be used to determine the inflammatory reaction and severity of pathological processes after thermal injury.

Keywords: thermal injury; acute phase proteins; haptoglobin; ceruloplasmin; C-reactive protein

Full text: (PDF, in Ukrainian)

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