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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(5): 17-21


Elastolitic system of pancreas at modellingdiabetes melitus

M.V. Borysyuk, V.Ye. Dosenko, Yu.V. Byts

    A.A.Bogomoletz Medical University, Kiev


Abstract

At modelling streptozotocin and alloxan diabetes melitus in rats we have detected an imbalance between elastase and its inhibitors (alpha 1 inhibitor of protein kinases, alpha-2 macroglobulin, acid-thermoresistant inhibitors) in tissues of the pancreas. The contribution of proelactase decreased but that of an active form of protein kinase increased; the content of alpha 1 inhibitor of protein kinase and alpha 2 macroglobulin reduced, however the contribution of the acid-thermoresistant inhibitors in the pancreatic tissues in- creased. Imbalance in the system elastase- inhibitors, shown at the model of diabetes mellitus, may be an important mechanism of an exocrine unsufficiency of the pancreas which results in pancreatitis.

Keywords: diabetes melitus, rats

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