In more than 10% of patients who use fixed dental prosthetic structures, gingivitis and stomatitis are observed. The aim of our research was to study cytokine status changes in rats with experimental bacterialimmune periodontitis and under the conditions of using stamped and solid-cast fixed prosthetic constructions Experimental bacterial-immune periodontitis was induced by injecting a mixture of microorganisms, diluted with egg protein, into the periodontal complex tissues. On the 30th day of the experiment, the blood serum levels of interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and interleukin-10 (IL-10) were determined using the Solid-phase enzyme immunoassay. In animals with periodontitis and solid-cast crowns, there was a significant increase in the production of pro-inflammatory cytokines (IL-1β and IL-6) and a decrease in the formation of anti-inflammatory cytokine IL-10, compared to the data in rats with the use of stamped constructions. The obtained results indicate a differential influence of prosthetics type on the periodontal inflammation development.