It was shown that the combined oral use of drugs with a metabolic effect - armadine at a dose of 300 mg per day and trizipin at a dose of 500 mg per day for 60 days led to inhibition of the oxidative stress damaging effect on its molecular genetic targets - proteins, lipids, and DNA - in blood of patients with type 2 diabetes mellitus (DM2). This is evidenced by a decrease in the proteins’ oxidative modification level and the content of lipid peroxidation secondary products in blood plasma and changes in the expression of the transcription factor HIF-1α and the regulatory protein mTOR genes in leukocytes of patients with DM2. This occurred against the background of a fall in the hydrogen peroxide production in erythrocytes of patients with DM2 and an increase in the activity of antiradical defense and the glutathione antioxidant system in plasma and erythrocytes of these patients after treatment. Genetic studies indicated that the use of armadine in combination with trizipin significantly raised the expression of the HIF-1α gene and reduced the decrease in the expression of the mTOR gene in blood leukocytes of patients with type 2 diabetes mellitus. The established changes can serve as a protective mechanism that counteracts the development of oxidative damage of macromolecules through various signaling metabolic pathways.