Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2024; 70(1): 37-42

Detection of herpes viruses in patients with classical trigeminal neuralgia

V.O. Fedirko, I.G. Vasilyeva, N.G. Chopyck, O.I. Tsjubko, T.A. Makarova, A.B. Dmitrenko

    SI “Institute of Neurosurgery n. acad. A.P. Romodanov NAMS of Ukraine”, Kyiv, Ukraine


A comparison of the presence frequency of herpes viruses HSV1/2, VZV, HHV-6, HHV-7, EBV, CMV was conducted in 430 patients with classical trigeminal neuralgia (TN) using RT PCR method. In the venous blood of patients with paroxysmal pain syndrome (TNP) and persistent background pain (TNB), herpes viruses were detected in 36.3% (97/267) and 80.4% (131/163) cases, respectively. The effectiveness of microvascular decompression and long-term outcomes were assessed depending on the presence of herpes viruses. Pain syndrome completely regressed in 404 out of 430 patients (93.9%), partially in 25 patients (5.8%), and persisted in 1 patient (0.2%). In TNB group, pain recurrence and partial regression were observed more frequently (20.2% (34/163) and 12.8% (21/163), respectively) if compared to TNP group (1.8% (5/267) and 1.5% (4/267), respectively). Complete pain regression in TNB group was less than in TNP group: 86.5% (141/163) and 98% (263/267), respectively. The presence of herpes viruses in patients with TN, a higher frequency of detection of herpes viruses, as well as a higher percentage of patients with recurrence of pain in TNB versus TNP group suggest a potential role of herpes viruses in the development of pain syndrome. Thus, studying herpes viruses in the blood could be recommended for improving the diagnostics and therapy of patients with classical TN.

Keywords: classical trigeminal neuralgia; herpes viruses; HSV1/2; VZV; HHV-6; HHV-7; EBV; CMV


  1. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013 Jul;33(9):629-808. CrossRef PubMed
  2. Wu M, Jiang X, Qiu J, Fu X, Niu C. Gray and white matter abnormalities in primary trigeminal neuralgia with and without neurovascular compression. J Headache Pain. 2020 Nov 25;21(1):136. CrossRef PubMed PubMedCentral
  3. Antonini G, Di Pasquale A, Cruccu G, Truini A, Morino S, Saltelli G, Romano A, Trasimeni G, Vanacore N, Bozzao A. Magnetic resonance imaging contribution for diagnosing symptomatic neurovascular contact in classical trigeminal neuralgia: a blinded case-control study and meta-analysis. Pain. 2014 Aug;155(8):1464-71. CrossRef PubMed
  4. Hamlyn PJ. Neurovascular relationships in the posterior cranial fossa, with special reference to trigeminal neuralgia. 1. Review of the literature and development of a new method of vascular injection-filling in cadaveric controls. Clin Anat. 1997;10(6):371-9. CrossRef
  5. Jani RH, Hughes MA, Gold MS, Branstetter BF, Ligus ZE, Sekula RF Jr. Trigeminal nerve compression without trigeminal neuralgia: intraoperative vs imaging evidence. Neurosurgery. 2019 Jan 1;84(1):60-5. CrossRef PubMed PubMedCentral
  6. Araya EI, Claudino RF, Piovesan EJ, Chichorro JG. Trigeminal neuralgia: Basic and clinical aspects. Curr Neuropharmacol. 2020;18(2):109-19. CrossRef PubMed PubMedCentral
  7. Bello-Morales R, Andreu S, López-Guerrero JA. The role of herpes simplex virus type 1 infection in demyelination of the central nervous system. Int J Mol Sci. 2020 Jul 16;21(14):5026. CrossRef PubMed PubMedCentral
  8. Ptaszyńska-Sarosiek I, Dunaj J, Zajkowska A, Niemcunowicz-Janica A, Król M, Pancewicz S, et al. Postmortem detection of six human herpesviruses (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6) in trigeminal and facial nerve ganglia by PCR. Peer J. 2019 Jan 9;6:e6095. CrossRef PubMed PubMedCentral
  9. Suenaga T, Satoh T, Somboonthum P, Kawaguchi Y, Mori Y, Arase H. Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses. Proc Natl Acad Sci USA. 2010 Jan 12;107(2):866-71. CrossRef PubMed PubMedCentral
  10. Skuja S, Svirskis S, Murovska M. Human hepesvirus-6 and -7 in the brain microenvironment of persons with neurological pathology and healthy people. Int J Mol Sci. 2021 Feb 27;22(5):2364. CrossRef PubMed PubMedCentral
  11. Leroy H, Han M, Woottum M, Bracq L, Bouchet J, Xie M, et al. Virus-mediated cell-cell fusion. Int J Mol Sci. 2020 Dec 17;21(24):9644. CrossRef PubMed PubMedCentral
  12. Sundaresan B, Shirafkan F, Ripperger K, Rattay K. The role of viral infections in the onset of autoimmune diseases. Viruses. 2023 Mar 18;15(3):782. CrossRef PubMed PubMedCentral
  13. Houen G, Trier NH, Frederiksen JL. Epstein-Barr Virus and multiple sclerosis. Front Immunol. 2020 Dec 17;11:587078. CrossRef PubMed PubMedCentral
  14. Serafini B, Rosicarelli B, Veroni C, Mazzola GA, Aloisi F. Epstein-Barr Virus-Specific CD8 T cells selectively infiltrate the brain in multiple sclerosis and interact locally with virus-infected cells: Clue for a virus-driven immunopathological mechanism. J Virol. 2019 Nov 26;93(24):e00980-19. CrossRef PubMed PubMedCentral
  15. Gambeta E, Chichorro JG, Zamponi GW. Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments. Mol Pain. 2020 JanDec;16:1744806920901890. CrossRef PubMed PubMedCentral
  16. Fedirko VO, Vasylieva IH, Kononenko VV, Havrysh RV, Chopyk NH. Bolovi syndromy v diliantsi oblychchia, holovy, shyi, poviazani z herpes-virusamy. Annaly Mechnykivskoho Inst. 2003;(4-5):60-6. [Ukrainian].
  17. Zakrzewska JM, Coakham HB. Microvascular decompression for trigeminal neuralgia: update. Curr Opin Neurol. 2012 Jun;25(3):296-301. CrossRef PubMed
  18. default.aspx Online calculator.
  19. jamovi project (2022). jamovi. (Version 2.3) [Computer Software].
  20. Fedirko VO, Nosov AT, Shmelova HA. Osoblyvosti etiopatohenezu syndromiv hiperaktyvnoi dysfunktsii cherepnykh nerviv. Patolohiia. 2009;6(3):104-9. [Ukrainian].

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.